ENDOPHENOTYPE, INTERMEDIATE PHENOTYPE, BIOMARKER: DEFINITIONS, CONCEPT COMPARISONS, CLARIFICATIONS: The Cutting Edge: Endophenotype, Intermediate Phenotype, and Biomarker
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Biomarkers must indicate active disease, whereas intermediate phenotypes do not.
“What is critical to remember is that biomarkers must indicate active disease, whereas intermediate phenotypes do not.”
From Addiction Biomarkers: Dimensional Approaches to Understanding Addiction (2018) · cites this paper as [15]
A biomarker may be indicative of active disease, while an intermediate phenotype comprises a stepping-stone in the progress to disease.
“While sometimes used interchangeably, the distinction is important: a biomarker may be indicative of active disease, while an intermediate phenotype comprises a stepping-stone in the progress to disease [15].”
From Addiction Biomarkers: Dimensional Approaches to Understanding Addiction (2018) · cites this paper as [15]
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References 29 · Cited by 84
Research works printed but not linked: 3
- Gottesman II, Shields J. Schizophrenia and Genetics: A Twin Study Vantage Point. New York: Academic Press; 1972.
- Shields J, Gottesman II. Genetic studies of schizophrenia as sign- posts to biochemistry. Biochem Soc Spec Publ 1973;1:165-174.
- Depression and Anxiety 15206394, 2013, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/da.22042 by Mount Vernon Nazarene University, Wiley Online Library on [10/09/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI
- Authors
- Lenzenweger, M. F.
- Affiliations
- Binghamton University (US)
- Corresponding author
- Lenzenweger, Mark F.
- ORCID
- Lenzenweger, Mark F.
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2013-01-16
- Volume
- 30
- Issue
- 3
- Pages
- 185-189
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W2122594349
- Cited by
- 84
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 9 · 2014: 10 · 2013: 5
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- endophenotypes, biomarkers, definitions, concept comparison, psychiatric genetics
- MeSH terms
- Humans, Terminology as Topic, Phenotype, Biomarkers, Endophenotypes
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