NEUROANATOMIC ABNORMALITIES IN ADOLESCENTS WITH GENERALIZED ANXIETY DISORDER: A VOXEL-BASED MORPHOMETRY STUDY: Research Article: Neuroanatomy of Pediatric GAD
Abstract
BACKGROUND: Despite recent data implicating functional abnormalities in the neurocircuitry underlying emotional processing in pediatric anxiety disorders, little is known regarding neurostructural abnormalities within these systems. METHODS: Using voxel-based morphometry, gray and white matter volumes were compared in 15 medication-free adolescents with generalized anxiety disorder (GAD; and no comorbid major depressive disorder) and 28 age- and sex-matched healthy comparison subjects. RESULTS: Compared to healthy adolescents, youth with GAD had larger gray matter volumes in the right precuneus and right precentral gyrus and decreased gray matter volumes in the left orbital gyrus and posterior cingulate. White matter volumes were decreased in the left medial and superior frontal gyrus and were increased in the left inferior temporal gyrus in youth with GAD relative to healthy subjects. CONCLUSIONS: Adolescents with GAD, who are early in the course of their illness, exhibit abnormalities in neural structures that subserve threat appraisal, modulation of fear responses, attachment, and mentalization.
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There is some evidence of similar structural abnormalities in ventral portions of the prefrontal cortex and the uncinate fasciculus for anxious youth.
“While the number of studies examining structural changes in anxious vs. non-anxious adolescents is low, there is some evidence of similar structural abnormalities in ventral portions of the prefrontal cortex and the uncinate fasciculus for anxious youth29–34.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [29]
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References 66 · Cited by 107
- Authors
- Strawn, J. R., Wehry, A. M., Chu, W.-J., Adler, C. M., Eliassen, J. C., Cerullo, M. A., Strakowski, S. M., & DelBello, M. P.
- Affiliations
- University of Cincinnati (US)
- Corresponding author
- Strawn, Jeffrey R.
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2013-03-11
- Volume
- 30
- Issue
- 9
- Pages
- 842-848
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W1917311052
- Cited by
- 107
- References
- 66
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 9 · 2016: 12 · 2015: 8 · 2014: 9 · 2013: 1
- FWCI
- 13.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000077)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- generalized anxiety disorder, adolescents, neuroanatomical abnormalities, gray matter volume, white matter volume, precuneus, precentral gyrus, orbital gyrus, posterior cingulate cortex, frontal gyrus, inferior temporal gyrus, threat appraisal, fear response, attachment, mentalization
- MeSH terms
- Adolescent, Anxiety Disorders, Brain, Brain Mapping, Child, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Organ Size, Parietal Lobe, Temporal Lobe, Case-Control Studies, Nerve Fibers, Unmyelinated
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