Defining treatment‐resistant depression

Cited by (446)

Items 401–446 of 446

1. Analysis of factors associated with treatment-resistant depression in patients with depression in Parkinson’s disease (DPD)
   Junfen Tang, Weikun Zheng, Yingjun Ouyang, Jun Dong, Bing Qin · 2025 · Neurological Research
2. Increased Aperiodic Exponents Track Depression Symptom Severity
   Mark R. Libowitz, Wendy Sun, Rebecca J. Rabinovich, Jingnan Du, Justin M. Campbell, Rhiannon L Cowan, Niloufar Shahdoust, T. Alexander Price, Tyler S. Davis, Randy L. Buckner et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
3. Additional file 1 of Cervical muscle stiffness and parasympathetic nervous system improvements for treatment-resistant depression
   Takayoshi Matsui, Hara, Kazuhiro, Iwata Makoto, Shuntaro Hojo, Nobuyuki Shitara, Yuzo Endo, Hideoki Fukuoka, Masaki Matsui, Kawaguchi, Hiroshi · 2022 · Figshare
4. Additional file 2 of Cervical muscle stiffness and parasympathetic nervous system improvements for treatment-resistant depression
   Takayoshi Matsui, Hara, Kazuhiro, Iwata Makoto, Shuntaro Hojo, Nobuyuki Shitara, Yuzo Endo, Hideoki Fukuoka, Masaki Matsui, Kawaguchi, Hiroshi · 2022 · Figshare
5. Discovery of 2,4-Disubstituted Pyrimidine Derivatives as Novel Kir4.1 Inhibitors with Rapid-Onset Antidepressant Effect
   Sisi Wang, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Yunpeng Guo, Hao Gu, Li Zhan, Yongjie Cai, Tianyu Tu et al. · 2026 · Journal of Medicinal Chemistry
6. Optimizing Treatment: Case Series of a Time-Efficient Accelerated Intermittent Theta Burst Stimulation Protocol for Depression and Call for a Protocol Consensus in Clinical Trials
   Doğukan Koçyiğit, İrem Kübra Nur Canpolat, Şeref Can Gürel · 2026 · Psychiatry Investigation
7. Which clinical factors and biochemical parameters differentiate major depressive disorder with versus without lifetime psychotic symptoms?
   Cecilia Maria Esposito, Francesca Legnani, Jennifer Lynn Barkin, Alessandro Ceresa, Guido Nosari, Martina Di Paolo, Luisa Cirella, Teresa Surace, Ilaria Tagliabue, Enrico Capuzzi et al. · 2026 · International Journal of Psychiatry in Clinical Practice
8. Early response to psilocybin in adults with treatment-resistant depression as a predictor for antidepressant efficacy
   Zoe Doyle, Noah Chisamore, Erica S. Kaczmarek, Danica E. Johnson, Ryan M. Brudner, Geneva Weiglein, Marc G. Blainey, Jordan Bawks, Jeremy Riva-Cambrin, Rickinder Sethi et al. · 2026 · General Hospital Psychiatry
9. Adherence and Engagement in Videoconference Interventions for Treatment-resistant Depression
   Adoración Castro, Pau Riera Serra, Guillem Navarra‐Ventura, Inés Forteza-Rey, Miquel Bennasar‐Veny, Aurora García-Robles, Joan Salvá, Olga Ibarra, Rocío Gómez-Juanes, Mauro Garcı́a-Toro · 2026 · Clínica y Salud
10. Modulatory effects of ketamine on EEG source-based resting state connectivity in treatment resistant depression
    Ty Lees, Jason N. Scott, Brian W. Boyle, Shiba M. Esfand, Samantha R. Linton, Courtney Miller, Mohan Li, Sarah E. Woronko, Rebecca Dunayev, Mario Bogdanov et al. · 2026 · Translational Psychiatry
11. A systematic review of transcranial magnetic stimulation for generalized anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder
    Shivani M. Reddy, Caroline B. Rains, Valerie C. Ng, Shannon Kugley, Colleen Ovelman, Bradley Neil Gaynes, Leila C. Kahwati · 2026 · BMC Psychiatry
12. Defining treatment-resistant depression in a real-world setting: impact of a staging model on clinical features and treatment trajectories
    Matteo Carminati, Mattia Tondello, Chiara Morana, Alessandro Serretti, Raffella Zanardi · 2026 · International Clinical Psychopharmacology
13. Assessment of glymphatic function in treatment-resistant depression using DTI-ALPS index
    Xin Zhang, Shaoyong Ye, Maoxin Zhang, Xinyi Ye, Xuanqiang Chen, Ziqi Chen, Qing Jiao, Manli Huang, Dong Cui · 2026 · Journal of Affective Disorders
14. Understanding response to treatment in depression: Insights from the Pakistani DIVERGE study
    Muhammad Umar, Fahad Hussain, Bakht Khizar, Inzemam Khan, Fahadullah Khan, Marius Cotic, Lian Chan, Ashfaq Hussain, Mian Nizam Ali, Shamshad Ahmed Gill et al. · 2026 · medRxiv
15. Effectiveness and mechanisms of Intensive Short-Term Dynamic Psychotherapy for treatment-resistant depression: a reanalysis of a randomized controlled trial
    Robert Johansson, Peter Lilliengren · 2026 · Frontiers in Psychiatry
16. Changes in the orexin system, hypothalamic-pituitary-adrenal axis and circadian rhythm in juvenile-stressed rats
    Kazune Ozaki, Shinya Nishiide, Hiroki Shikanai, Tsugumi Shindo, Riho Mabuchi, Satoshi Shinozuka, Takeshi Izumi · 2026 · Journal of Pharmacological Sciences
17. Structural and functional brain correlates of treatment-resistant depression: A systematic review of magnetic resonance imaging studies
    Lauren E. Carter, Emily Lowery, Mitul Ashok Mehta, Allan Hunter Young · 2026 · Journal of Affective Disorders
18. Clinical trials in depression: Integrated collection across EU and US registries
    Kate Stewart, Louise S. Schindler, Robert Bevan, Samrina Rehman, Matthew H. Iveson, Andrew Mark McIntosh, Naomi R. Wray, Cathryn M. Lewis · 2026 · Wellcome Open Research
19. Neuroimmune Dysregulation and the Role of IL-10 in Depression: A Systematic Review
    José Luis Cortes-Altamirano, Alfonso Alfaro-Rodríguez, Angélica González-Maciel, Beatríz Pérez-Guillé, Rosa Eugenia Soriano‐Rosales, Herlinda Bonilla Jaime, Alberto Ávila-Luna, Antonio Bueno-Nava, Pedro Sánchez-Aparicio, Ana Lilia Dotor-Llerena · 2026 · Brain Sciences
20. Introduction to Disability Care in Major Depressive Disorder
    Ajay Kumar, Juveriya Israr, Shabroz Alam · 2026 · SpringerBriefs in modern perspectives on disability research.
21. Change in the Use of Electroconvulsive Therapy Between 2012 and 2022 in Northern Finland
    Matias Leppäaho, Saana Karttunen, Marianne Haapea, Anna-Sofia Myllynen, Helinä H Hakko, Erika Jääskeläinen · 2026 · Journal of Ect
22. Changes in the Use of Repetitive Transcranial Magnetic Stimulation Therapy Between 2016 and 2022 in Northern Finland
    Saana Karttunen, Matias Leppäaho, Marianne Haapea, Helinä H Hakko, Erika Jääskeläinen · 2026 · Journal of Ect
23. The relevance of phenotypic definition in treatment resistant forms of major depressive disorder: a narrative review
    Pasquale Paribello, Ulker Isayeva, Silvia Lazzardi, M A Pinna, Martina Contu, Anna Meloni, Claudia Pisanu, Alessio Squassina, Bernhard Theodor Baune, Mirko Manchia · 2026 · Frontiers in Pharmacology
24. Predicting changes in depressive symptomatology following oral esketamine treatment in treatment-resistant depression: A machine-learning approach
    Juliana Lima Constantino, Tobias Stephan Freimann, Jens H. van Dalfsen, Annemarie van der Meij, Jolien K. E. Veraart, Sanne Y. Smith-Apeldoorn, Robert A. Schoevers, Jeanine Kamphuis · 2026 · Journal of Psychiatric Research
25. Add-on tocilizumab versus placebo for resistant major depression in psychiatric outpatients with low-grade inflammation in a tertiary public hospital in Southern Brazil: randomised triple-blind clinical trial protocol
    Pedro Henrico Grazziotin Portal, Graziella Nunes Peixoto, Marina Ribeiro de Matos, L C. S. Silva, Giulio Bertollo Alexandrino, Paulo Henrique Dutra, Bruno Perosa Carniel, Neusa Sica da Rocha · 2026 · BMJ Open
26. Psychedelics in treatment-resistant depression: a comprehensive review of mechanisms, clinical evidence, and recommendations
    Cielo Amelia Estela-Fernandez, Reem Mohamed Yousif Elsheikh, D F Beatrice, Abdullah A. Alhendal, Chinonso Irene Ewe, Sebastian Y. Montesinos, Jocelyn Wensel, Anushka P Mishra, Asma Ahmed Yousif, Hossam Tharwat Ali · 2026 · Neuropsychiatrie
27. Increased Aperiodic Exponents Track Depressive Symptom Severity in Refractory Epilepsy
    Mark R. Libowitz, Wendy Sun, Rebecca J. Rabinovich, Jingnan Du, Justin M. Campbell, Rhiannon L Cowan, Niloufar Shahdoust, T. Alexander Price, Tyler S. Davis, Randy L. Buckner et al. · 2026 · Biological Psychiatry Cognitive Neuroscience and Neuroimaging
28. Multimodal Behavior Scoring Quantifies Depression-like Severity Across Chronic Stress Models and Identifies Stress-Resilient Mice
    Yue Tu, Qinghui Fu, Yixin Li, Canghao Sun, Yanan Zhu, Xianlin Zeng, Haoning Qin, Xianlin Zeng, Yuchuan Wang, Shulan Qiu et al. · 2026 · NeuroSci
29. Serum brain-derived neurotrophic factor following oral esketamine in treatment-resistant depression: Results from a randomized placebo-controlled trial
    Sara Massetti, Sanne Y. Smith-Apeldoorn, Jolien K. E. Veraart, Jeanine Kamphuis, Kobold Anneke Muller, Eleni T. Tzavara, Peter Meerlo, Robert A. Schoevers, Jens H. van Dalfsen · 2026 · Journal of Affective Disorders
30. A Phase 2 randomised, double-blind, placebo-controlled trial of emestedastat in patients with major depressive disorder and cognitive impairment
    Jack D. Taylor, Paul Edward Rolan, Mark Jaros, John E. Harrison, Stuart H. Ratcliffe, Michael Berk, Dana C. Hilt · 2026 · The British Journal of Psychiatry
31. Global and item-level MADRS differences between melancholic and unspecified depressive symptoms under rTMS: an exploratory analysis
    Carolina Viegas, Setareh Ranjbar, Jean‐Frédéric Mall, Pierre Vandel, Armin von Gunten, Beatriz Pozuelo Moyano, Kevin Swierkosz-Lenart · 2026 · Frontiers in Psychiatry
32. Diazepam, a positive allosteric modulator of the GABAA receptor, induces strain-specific responses in object recognition, ultrasonic vocalizations and monoaminergic profiles in the Wistar Kyoto rat model of endogenous depression
    Akshata T. Inavally, Monika Sadananda · 2026 · Neuroscience Letters
33. The functional role of ERK activity in esketamine's antidepressant effects
    P X Zhang, Mengyu Wu, Keke Zhang, Jiajing He, Xingxing Liu, Hongxing Zhang, A Z Hu, Wu Zhou · 2026 · Pharmacology Biochemistry and Behavior
34. Resistant depression, biomarkers, and comorbidity in clinical practice
    Alessandro Serretti · 2026 · International Clinical Psychopharmacology
35. Long-term cognitive effects after SCG-DBS in patients with treatment resistant depression: A 5-year follow-up
    Muriel Vicent-Gil, Joan Trujols, Dolors Puigdemont, Marı́a J. Portella, Carlo Alemany, Víctor Serrano-Gimeno, Juan Ángel Aibar‐Durán, Rodrigo Rodríguez Rodríguez, Emilio Ros, Montserrat Cofán et al. · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
36. Biological Non-pharmacological Treatments for Depressive Disorder
    Min‐Kyu Song, Jeong Seok Seo · 2026 · Springer eBooks
37. Bipolar spectrum disorders in apparent treatment-resistant depression: diagnostic pitfalls and implications for contemporary psychiatric practice
    Mohammed Al‐Alawi, Abdullah Al Ghailani, Ahmed Al Harrasi, Manal Al Balushi, Nasr Al Balushi, Hamed Al Sinawi · 2026 · BJPsych Advances
38. Intranasal biomaterials for treatment-resistant depression: device–formulation coupling and therapeutic exposure
    Wetao Wu, Jiali He, Jiaxin Hu, Xin Xu, M.X. Yang, Fei Wen · 2026 · Frontiers in Bioengineering and Biotechnology
39. Ketamine and Its Enantiomer(s) Therapy to Treat Major Depressive Disorder: Clinical Relevance and Underlying Mechanisms
    Joel Kallarackal, Brandon J. Dyer, Jeffrey Huang · 2026 · Springer eBooks
40. Psychedelic therapy without durable effects: A review and re-evaluation of controlled studies between 1965 and 1977.
    Torsten Passie, M. van Elk · 2026 · Journal of Psychopharmacology
41. Treatment-Resistant Depression as a Heterogeneous Clinical Syndrome: A Personalized Medicine Framework for Diagnostic Reassessment, Suicide Risk, and Mechanism-Based Treatment
    Davoud Amiri, Swetang J Shah, Lamberto Briziarelli, Sara Amiri, Barry Karlsson · 2026 · Journal of Personalized Medicine
42. Default mode network functional connectivity following treatment with conventional antidepressants and (es)ketamine in major depressive disorder: A systematic review
    Juliana Lima Constantino, Jesca E. De Jager, Jasper O. Nuninga, Jeanine Kamphuis, Robert A. Schoevers, Jens H. van Dalfsen · 2026 · Psychiatry Research Neuroimaging
43. An Overview of Depression Pathogenesis: Prevailing Hypotheses and Associated Neurobiological Underpinnings Primarily Evidenced by Rodent Studies
    Bo Zhang, Chuanyu Li · 2026 · Depression and Anxiety
44. Treatment-resistant depression management in postpartum depression – a case report and literature review
    Iqra Sohail, Pongsirilux Laveewan, Grace Bach, Shabab Islam, Ravi L. Maharaj, Rosy Sinha, Himani J Suthar, Luis Rodriguez, Aileen Wan, Eric Wang et al. · 2026 · International Journal of Community Medicine and Public Health
45. Variability in Sertraline Pharmacokinetics in Routine Clinical Practice: Influence of Sex, Age, Body Weight, Smoking, and Co‐Medication
    Begoña Tapia-Alzuguren, Covadonga Canga-Espina, Patricio Molero, Azucena Aldaz · 2026 · Fundamental and Clinical Pharmacology
46. The severity of treatment-resistant depression and the response to repetitive transcranial magnetic stimulation: a prospective, observational, multi-center clinical cohort study
    Lea Holst, Ana Lisa Carmo, Maria Simonsen Speed, Marie Borg Kusk Petersen, Sónia Pimenta, Pernille Kølbæk, Christiane Gasse · 2026 · Nordic Journal of Psychiatry