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Cited by 22

The DOI matches its Crossref record.

Isorhamnetin‐3‐O‐Glucuronide Suppresses JNK and p38 Activation and Increases Heme‐Oxygenase‐1 in Lipopolysaccharide‐Challenged RAW264.7 Cells

Park, Jin‐Young, Kim, Song‐In, Lee, Hee Jae, Kim, Sung‐Soo, Kwon, Yong‐Soo, Chun, Wanjoo·2016·Drug Development Research
DOI 10.1002/ddr.21301
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Abstract

Preclinical Research Isorhanmetin (ISH) exhibits a wide range of biological properties including anticancer, anti‐oxidant and anti‐inflammatory activities. However, the pharmacological properties of isorhamnetin‐3‐O‐glucuronide (IG), a glycoside derivative of ISH, have not been extensively examined. The objective of this study was to examine the anti‐inflammatory properties of IG and its underlying mechanism in lipopolysaccharide (LPS)‐challenged RAW264.7 macrophage cells in comparison with its aglycone, ISH. IG suppressed LPS‐induced extracellular secretion of the proinflammatory mediators, nitric oxide (NO) and PGE 2, and proinflammatory protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2. IG also increased expression of heme oxygenase‐1 (HO‐1). IG attenuated LPS‐induced activation of c‐Jun N‐terminal kinase (JNK) and p38 in a concentration‐dependent manner with negligible suppression of extracellular signal‐regulated kinases (ERK) phosphorylation. In conclusion, this study demonstrates that IG exerts anti‐inflammatory activity by increasing HO‐1 expression and by suppressing JNK and p38 signaling pathways in LPS‐challenged RAW264.7 macrophage cells. Drug Dev Res 77 : 143–151, 2016. © 2016 Wiley Periodicals, Inc.

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Cited by

Metadata

Authors
Park, J., Kim, S., Lee, H. J., Kim, S., Kwon, Y., & Chun, W.
Affiliations
  • Department of Pharmacology College of Medicine, Kangwon National University Chuncheon 200‐701 Korea
  • College of Pharmacy Kangwon National University Chuncheon 200‐701 Korea
Venue
Drug Development Research
Publisher
Wiley
Published
2016-04-25
Volume
77
Issue
3
Pages
143-151
ISSN
  • 0272-4391
  • 1098-2299
DOI
10.1002/ddr.21301
Cited by
22
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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