The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs
Abstract
Prostaglandins have been shown to be involved in many different biological processes, under both normal and pathological conditions. As the key enzyme in the production of prostaglandins and thromboxanes, prostaglandin GIH synthase (PGHS) has been well characterized, including extensive studies as a pharmacological target of the nonsteroidal antiinflammatory drugs (NSAIDs). The gene for this enzyme has been cloned, sequenced, and characterized from sheep, mouse, and human sources. Recently, a new form of this enzyme, a mitogen‐inducible PGHS (miPGHS), was identified. Comparisons between these two genes and their protein products have identified significant differences, including structural differences in the proteins and their mRNAs. The genes encoding these two isoenzymes are not coordinately regulated in cultured cells or in tissues. The discovery of this second form of PGHS may change our understanding of how NSAlDs exert their effects. miPGHS is believed to be a new, unique target of NSAIDs which could have a different sensitivity to many of these drugs, compared to the previously identified PGHS. © 1992 Wiley‐Liss, Inc.
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Cites
FLOWER, R. J., & VANE, J. R. (1972) · Nature · doi:10.1038/240410a0 · Cited by 779
Sprecher, H., VanRollins, M., Sun, F., Wyche, A., & Needleman, P. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34869-5 · Cited by 76
Cited by
Oshima, M., Dinchuk, J. E., Kargman, S. L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J. M., Evans, J. F., & Taketo, M. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81988-1 · Cited by 2,366
Langenbach, R., Morham, S. G., Tiano, H. F., Loftin, C. D., Ghanayem, B. I., Chulada, P. C., Mahler, J. F., Lee, C. A., Goulding, E. H., Kluckman, K. D., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90126-4 · Cited by 1,123
Vane, J. (1994) · Nature · doi:10.1038/367215a0 · Cited by 699
Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs
Vane, J. R., & Botting, R. M. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00203-9 · Cited by 688
Swierkosz, T. A., Mitchell, J. A., Warner, T. D., Botting, R. M., & Vane, J. R. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13353.x · Cited by 342
Metadata
- Authors
- Xie, W., Robertson, D. L., & Simmons, D. L.
- Venue
- Drug Development Research
- Publisher
- Wiley
- Published
- 1992-01
- Volume
- 25
- Issue
- 4
- Pages
- 249-265
- ISSN
- 0272-4391 (ISSN-L)
- 1098-2299
- OpenAlex
- W2110769474
- Cited by
- 306
- References
- 2
- FWCI
- 19.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xie, W., Robertson, D. L., & Simmons, D. L. (1992). Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs. Drug Development Research. https://doi.org/10.1002/ddr.430250402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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