Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment
Abstract
This review will describe the neurocognitive outcomes associated with pediatric acute lymphoblastic leukemia (ALL) and its treatment. The literature is reviewed with the aim of addressing methodological issues, treatment factors, risks and moderators, special populations, relationship to neuroimaging findings, and directions for future research. It is concluded that neurocognitive outcomes for the majority of children with standard-risk ALL treated according to current chemotherapy protocols is relatively good, but subgroups of children are more significantly compromised. As medical treatments advance and survival rates continue to improve, neurocognitive outcomes and other quality of life indicators will become increasingly important. Preventing or ameliorating treatment-related neuropsychological sequelae represents the next major challenge in pediatric ALL.
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ALL treatment has changed dramatically since older survivors were diagnosed, with cranial radiation therapy almost entirely replaced by chemotherapy-only protocols.
“ALL treatment has changed dramatically since these older survivors were diagnosed (Pui & Evans, 2013; Simone, 2006): due to concerns of significant neuropsychological effects (Janzen & Spiegler, 2008; Spiegler et al., 2006), cranial radiation therapy has almost entirely been replaced by chemotherapy‐only protocols (Pui & Evans, 2013; Pui et al., 2009).”
From Brain structure, working memory and response inhibition in childhood leukemia survivors (2017) · cites this paper as Janzen & Spiegler, 2008
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References 132 · Cited by 47
- Authors
- Janzen, L. A., & Spiegler, B. J.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Janzen, Laura A.
- ORCID
- Janzen, Laura A.
- Venue
- Developmental Disabilities Research Reviews
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 14
- Issue
- 3
- Pages
- 185-195
- ISSN
- 1940-5510 (ISSN-L)
- 1940-5529
- OpenAlex
- W2048915172
- Cited by
- 47
- References
- 132
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Disabilities Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- childhood acute lymphoblastic leukemia, neuropsychological outcomes, treatment-related cognitive impairment, chemotherapy-induced neurotoxicity, neurodevelopmental sequelae, quality of life, neuroimaging, risk factors, standard-risk ALL
- MeSH terms
- Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Brain, Brain Damage, Chronic, Child, Developmental Disabilities, Child, Preschool, Cognition Disorders, Combined Modality Therapy, Humans, Infant, Prognosis, Radiation Injuries, Cranial Irradiation, Treatment Outcome, Survivors, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Young Adult
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