The effects of isolation rearing on open-field behavior in male rats depends on developmental stages
Abstract
The effects of the duration of isolation and age during isolation on open-field behavior in rats were examined. An inner wall divided the floor of the field into two areas, a peripheral alley and the center square, and the subjects' behavior in each area was measured. An increase in the tendency to avoid the center square was found in rats isolated during their juvenile stage, which disappeared if they were reared in pairs for a long period after isolation. On the other hand, subjects isolated during their postmaturity stage displayed an increased tendency to approach the center square whereas isolation during sexual maturity had no effect. The duration of isolation showed no consistent effect; rather, the effect depended on the age of the subjects during isolation. These findings suggest that isolation affects the open-field behavior of rats in various ways, depending on their age during isolation.
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Juvenile social isolation in rats increases anxiety- and depression-like behavior.
“increases anxiety- and depression-like behavior (Parker and Morinan, 1986; Wright et al., 1991; Arakawa, 2003; Leussis and Andersen, 2008; Lukkes et al., 2009; Cuesta et al., 2020)”
From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Arakawa, 2003
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References 51 · Cited by 83
- Authors
- Arakawa, H.
- Affiliations
- Nagoya University (JP)
- Corresponding author
- Arakawa, Hiroyuki
- ORCID
- Arakawa, Hiroyuki
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2003-05-30
- Volume
- 43
- Issue
- 1
- Pages
- 11-19
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- OpenAlex
- W1968116531
- Cited by
- 83
- References
- 51
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- social isolation, isolation rearing, open field behavior, rats, developmental stages, postmaturity, sexual maturity, rearing conditions
- MeSH terms
- Aging, Animals, Arousal, Exploratory Behavior, Male, Motor Activity, Orientation, Psychosexual Development, Social Isolation, Rats, Wistar, Rats
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