Induction of beta‐cell resistance to hypoxia and technologies for oxygen delivery to transplanted pancreatic islets
Abstract
Hypoxia is believed to be a crucial factor involved in cell adaptation to environmental stress. Islet transplantation, especially with immunoisolated islets, interrupts vascular connections, resulting in the substantially decreased delivery of oxygen and nutrients to islet cells. Insulin-producing pancreatic beta cells are known to be highly susceptible to oxygen deficiency. Such susceptibility to hypoxia is believed to be one of the main causes of beta-cell death in the post-transplantation period. Different strategies have been developed for the protection of beta cells against hypoxic injury and for oxygen delivery to transplanted islets. The enhancement of beta-cell defense properties against hypoxia has been achieved using various techniques such as gene transfection, drug supplementation, co-culturing with stem cells and cell selection. Technologies for oxygen delivery to transplanted islets include local neovascularization of subcutaneous sites, electrochemical and photosynthetic oxygen generation, oxygen refuelling of bio-artificial pancreas and whole body oxygenation by using hyperbaric therapy. Progress in the field of oxygen technologies for islet transplantation requires a multidisciplinary approach to explore and optimize the interaction between components of the biological system and different technological processes. This review article focuses mainly on the recently developed strategies for oxygenation and protection from hypoxic injury - to achieve stable and…
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Hypoxic conditions and oxidative stress can also induce other stress pathways that result in β cell functional failure and apoptosis.
“Hypoxic conditions and oxidative stress can also induce other stress pathways that result in β cell functional failure and apoptosis.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [131]
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References 86 · Cited by 24
- Authors
- Lazard, D., Vardi, P., & Bloch, K.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Lazard, Daniel
- ORCID
- Bloch, Konstantin
- Venue
- Diabetes/Metabolism Research and Reviews
- Publisher
- Wiley
- Published
- 2012-09
- Volume
- 28
- Issue
- 6
- Pages
- 475-484
- ISSN
- 1520-7552 (ISSN-L)
- 1520-7560
- OpenAlex
- W1486798139
- Cited by
- 24
- References
- 86
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes/Metabolism Research and Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tel Aviv University
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- hypoxia, beta-cell death, islet transplantation, oxygen delivery, oxygenation, neovascularization, hyperbaric therapy, transfection, diabetes mellitus, normoglycemia
- MeSH terms
- Animals, Cell Separation, Genetic Engineering, Humans, Metallothionein, Oxygen, Vitamin E, Cell Hypoxia, Islets of Langerhans Transplantation, Cell Death, Neovascularization, Physiologic, Ischemic Preconditioning, Genes, bcl-2, Pancreas, Artificial, Vascular Endothelial Growth Factor A, Insulin-Secreting Cells, X-Linked Inhibitor of Apoptosis Protein, Glucagon-Like Peptide 1
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