Where frailty meets diabetes
Open accessAbstract
Diabetes is a chronic illness that has an effect on multiple organ systems. Frailty is a state of increased vulnerability to stressors and a limited capacity to maintain homeostasis. It is a multidimensional concept and a dynamic condition that can improve or worsen over time. Frailty is either physical or psychological or a combination of these two components. Sarcopenia, which is the age‐related loss of skeletal muscle mass and strength, is the main attributor to the physical form of frailty. Although the pathophysiology of diabetes is commonly focused on impaired insulin secretion, overload of gluconeogenesis and insulin resistance, newer insights broaden this etiologic horizon. Immunologic factors that create a chronic state of low‐grade inflammation – ‘inflammaging’ – have an influence on both the ageing process and diabetes. Persons with diabetes mellitus already tend to have an accelerated ageing process that places them at greater risk for developing frailty at an earlier age. The development of frailty – and sarcopenia – is multifactorial and includes nutritional, physical and hormonal elements; these elements are interlinked with those of diabetes. A lower muscle mass will lead to poorer glycaemic control through lower muscle glucose uptake. This leads to higher insulin secretion and insulin resistance, which is the stepping stone for diabetes itself. Copyright © 2016 John Wiley & Sons, Ltd.
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Metabolic disorders such as diabetes may be associated with an accelerated ageing process, and more rapid wasting is commonly seen within severe disease such as chronic kidney disease and heart failure.
“Research has shown that metabolic disorders, such as diabetes may be associated with an accelerated ageing process, and more rapid wasting is commonly seen within severe disease such as chronic kidney disease and heart failure.[43][44][45]”
From Changes in lean body mass with <scp>glucagon‐like peptide</scp> ‐1‐based therapies and mitigation strategies (2024) · cites this paper as [43]
The Introduction says people with diabetes tend to have an accelerated ageing process. The Frailty and diabetes section reports greater risk of malnutrition and weight loss in patients with diabetic nephropathy when dietary protein is restricted, but does not establish that more rapid wasting is common in chronic kidney disease generally or in heart failure. No page number is available in our copy. (LLM, conf=0.86)
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References 91 · Cited by 120
Research works printed but not linked: 4
- Morley JE. Frailty: diagnosis and man- agement. J Nutr Health Aging 2011; 15(8): 667-70.
- Rasmussen BB, Fujita S, Wolfe RR, et al. In- sulin resistance of muscle protein metabo- lism in aging. FASEB J 2006; 20(6): 768-9.
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- Authors
- Perkisas, S., & Vandewoude, M.
- Affiliations
- University of Antwerp (BE)
- Corresponding author
- Perkisas, Stany
- Venue
- Diabetes/Metabolism Research and Reviews
- Publisher
- Wiley
- Published
- 2016-01
- Volume
- 32
- Issue
- S1
- Pages
- 261-267
- ISSN
- 1520-7552 (ISSN-L)
- 1520-7560
- OpenAlex
- W2212689096
- Cited by
- 120
- References
- 91
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 7 · 2023: 7 · 2022: 16 · 2021: 23 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 1
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes/Metabolism Research and Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- frailty, diabetes mellitus, sarcopenia, inflammaging, insulin resistance, accelerated aging, muscle glucose uptake, glycemic control, low-grade inflammation, nutritional status, hormonal factors
- MeSH terms
- Cognitive Aging, Aged, Aged, 80 and over, Combined Modality Therapy, Congresses as Topic, Diabetes Mellitus, Type 2, Humans, Life Style, Severity of Illness Index, Frail Elderly, Diabetic Foot, Disease Progression, Evidence-Based Medicine, Sarcopenia, Precision Medicine
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