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Cited by 229Axon Guidance and Neuronal SignalingCell Adhesion Molecules ResearchNeurogenesis and neuroplasticity mechanisms

Regulation of axonal outgrowth and pathfinding by integrin–ecm interactions

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Myers,, Jonathan P., Santiago‐Medina, Miguel, Gomez, Timothy M.·2011·Developmental Neurobiology
DOI 10.1002/dneu.20931PMC PMC3192254
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Abstract

Developing neurons use a combination of guidance cues to assemble a functional neural network. A variety of proteins immobilized within the extracellular matrix (ECM) provide specific binding sites for integrin receptors on neurons. Integrin receptors on growth cones associate with a number of cytosolic adaptor and signaling proteins that regulate cytoskeletal dynamics and cell adhesion. Recent evidence suggests that soluble growth factors and classic axon guidance cues may direct axon pathfinding by controlling integrin-based adhesion. Moreover, because classic axon guidance cues themselves are immobilized within the ECM and integrins modulate cellular responses to many axon guidance cues, interactions between activated receptors modulate cell signals and adhesion. Ultimately, growth cones control axon outgrowth and pathfinding behaviors by integrating distinct biochemical signals to promote the proper assembly of the nervous system. In this review, we discuss our current understanding how ECM proteins and their associated integrin receptors control neural network formation.

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  • Collagen, laminin, fibritin and RGD in ECM scaffolds can interact with 11 integrins.

    “Collagen, laminin, fibritin and RGD in ECM scaffolds can interact with 11 integrins.[ 130 ]”

    From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [130]

    The ECM composition and function section identifies collagen, laminin and fibronectin as ECM components, and the Fibronectin section says its RGD-containing domain is recognized by several integrins (page numbers unavailable). The copy does not identify “fibritin” or establish that these scaffold components interact with exactly 11 integrins. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Integrins participate in dendritic and axonal growth and regeneration.

    “For instance, integrins participate in dendritic and axonal growth and regeneration (Myers et al. 2011; Fawcett 2017)”

    From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Myers et al. 2011

    The ‘Integrins encode substratum specificity’ section says integrins function in axon extension and reports improved regeneration in vivo after α9-integrin expression. The passages do not establish a role in dendritic growth; the reference to dendritic spine remodeling is a bibliography entry, not a finding discussed in the paper. Page numbers are unavailable in our copy. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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References 257 · Cited by 229

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Authors
Myers, Santiago‐Medina, M., & Gomez, T. M.
Affiliations
  • University of Wisconsin System (US)
  • University of Wisconsin–Madison (US)
Venue
Developmental Neurobiology
Publisher
Wiley
Published
2011-10-11
Volume
71
Issue
11
Pages
901-923
ISSN
  • 1932-8451 (ISSN-L)
  • 1932-846X
DOI
10.1002/dneu.20931
PMC
PMC3192254
OpenAlex
W2019962736
Cited by
229
References
257
Citations by year
2026: 9 · 2025: 16 · 2024: 7 · 2023: 20 · 2022: 12 · 2021: 12 · 2020: 11 · 2019: 15 · 2018: 22 · 2017: 16 · 2016: 16 · 2015: 17 · 2014: 16 · 2013: 19 · 2012: 12
FWCI
1.68
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Developmental Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (T32GM008692)
  • National Institute of Neurological Disorders and Stroke (R01NS041564, R56NS041564, NS 41564)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
axon growth, axon guidance, integrins, extracellular matrix, growth cones, axon guidance cues, cell adhesion, cytoskeletal dynamics, soluble growth factors, integrin signaling
MeSH terms
Animals, Cell Communication, Humans, Nervous System, Neural Pathways, Signal Transduction, Integrins, Growth Cones, Neurogenesis

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