Doping control analysis of trimetazidine and characterization of major metabolites using mass spectrometric approaches

Sigmund, Gerd; Koch, Anja; Orlovius, Anne‐Katrin; Guddat, Sven; Thomas, Andreas; Schänzer, Wilhelm; Thevis, Mario

doi:10.1002/dta.1680

Doping control analysis of trimetazidine and characterization of major metabolites using mass spectrometric approaches

Since January 2014, the anti‐anginal drug trimetazidine [1‐(2,3,4‐trimethoxybenzyl)‐piperazine] has been classified as prohibited substance by the World Anti‐Doping Agency (WADA), necessitating specific and robust detection methods in sports drug testing laboratories. In the present study, the im…