The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
VE‐Cadherin‐Cre‐recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells
Abstract
The ability to target gene deletion to a specific cellular compartment via the Cre/loxP system has been a powerful tool in the analysis of broadly expressed genes. Here, we report the generation of a transgenic mouse line in which expression of Cre‐recombinase is under the regulatory control of the VE‐Cadherin promoter. Temporal distribution and activity of the enzyme was evaluated with two independent Cre reporter lines. Histological analysis was performed throughout development and in the adult. Recombination of lox P sites with subsequent expression of β‐galactosidase or GFP was detected as early as E7.5 in endothelial cells of the yolk sac. Progressive staining of the embryonic vasculature was noted from E8.5–13.5; however, more contiguous reporter expression was only seen by E14.5 onward in all endothelial compartments including arteries, veins, and capillaries. In addition, we found Cre activity in lymphatic endothelial cells. Unlike other endothelial‐specific Cre mice, this model showed expression in the adult quiescent vasculature. Furthermore, the constitutive nature of the VE‐Cadherin promoter in the adult can be advantageous for analysis of gene deletion in pathological settings. Developmental Dynamics 235:759–767, 2006. © 2006 Wiley‐Liss, Inc.
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Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 4,859
Prox1 Function Is Required for the Development of the Murine Lymphatic System
Wigle, J. T., & Oliver, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81511-1 · Cited by 1,579
Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors
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Carmeliet, P., Lampugnani, M.-G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oosthuyse, B., Dewerchin, M., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81010-7 · Cited by 1,283
Self-citationCre recombinase: The universal reagent for genome tailoring
Nagy, A. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2<99::aid-gene1>3.0.co;2-b · Cited by 1,265
Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Wigle, J. T., Harvey, N., Detmar, M., Lagutina, I., Grosveld, G., Gunn, M. D., Jackson, D. G., & Oliver, G. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1505 · Cited by 943
Self-citationLampugnani, M. G., Corada, M., Caveda, L., Breviario, F., Ayalon, O., Geiger, B., & Dejana, E. (1995) · The Journal of cell biology · doi:10.1083/jcb.129.1.203 · Cited by 597
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Dejana, E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118997 · Cited by 366
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The bone marrow microenvironment at single-cell resolution
Tikhonova, A. N., Dolgalev, I., Hu, H., Sivaraj, K. K., Hoxha, E., Cuesta-Domínguez, Á., Pinho, S., Akhmetzyanova, I., Gao, J., Witkowski, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1104-8 · Cited by 936
Blood-brain barrier dysfunction and recovery after ischemic stroke
Jiang, X., Andjelkovic, A. V., Zhu, L., Yang, T., Bennett, M. V. L., Chen, J., Keep, R. F., & Shi, Y. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.001 · Cited by 936
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Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4323-06.2006 · Cited by 878
Fate tracing reveals the endothelial origin of hematopoietic stem cells
Zovein, A. C., Hofmann, J. J., Lynch, M., French, W. J., Turlo, K. A., Yang, Y., Becker, M. S., Zanetta, L., Dejana, E., Gasson, J. C., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.018 · Cited by 691
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Metadata
- Authors
- Alva, J. A., Zovein, A. C., Monvoisin, A., Murphy, T., Salazar, A., Harvey, N. L., Carmeliet, P., & Iruela‐Arispe, M. L.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2006-01-31
- Volume
- 235
- Issue
- 3
- Pages
- 759-767
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2125039061
- Cited by
- 455
- References
- 33
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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