Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors
Open accessAbstract
Retinoic acid (RA) signaling is important for multiple aspects of embryonic development and tissue homeostasis. Heterodimers of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) transduce RA signaling. It is not yet clear how the diversity of receptor combinations relates to the diversity of functions for RA. The expression patterns of three zebrafish RARs and four RXRs were reported recently. Here, we identify an additional RAR, a zebrafish RARgamma paralog, and two additional RXRs, duplicates of the previously identified RXRalpha and RXRgamma. Thus, the zebrafish genome contains duplicates of each RAR and RXR gene. All zebrafish RAR and RXR paralogs have overlapping and distinct areas of expression, as might be expected for duplicate genes in the process of diverging in function. By representing what is potentially the complete set of zebrafish RARs and RXRs, this study provides a valuable reference for future functional studies of the individual zebrafish RARs and RXRs. Developmental Dynamics 236:587–595, 2007. © 2006 Wiley‐Liss, Inc.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
rxrga is included in the co-enrichment list of melanocytes and iridophores.
“We also find a retinoic acid nuclear receptor subfamily member (rxrga) previously reported to be expressed in neural crest tissues [64]–[67].”
rxrga was previously reported to be expressed in neural crest tissues.
“previously reported to be expressed in neural crest tissues [64]–[67].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cited by
Sorted by citations
Higdon, C. W., Mitra, R. D., & Johnson, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067801 · Cited by 125 · see citing works
- Authors
- Waxman, J. S., & Yelon, D.
- Affiliations
- New York University (US)
- Corresponding author
- Yelon, Deborah
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2006-12-28
- Volume
- 236
- Issue
- 2
- Pages
- 587-595
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2137085552
- Cited by
- 64
- References
- 0
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 2
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Dynamics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL069594, F32HL083591)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- retinoic acid receptor, retinoid X receptor, zebrafish, gene expression patterns, paralogs, gene duplication, retinoic acid signaling, receptor heterodimers, RXRα, retinoid X receptor gamma, RARγ
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Molecular Sequence Data, Phylogeny, Zebrafish, Cluster Analysis, In Situ Hybridization, Sequence Analysis, DNA, Receptors, Retinoic Acid, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Retinoid X Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
