Hyaluronan is required for cranial neural crest cells migration and craniofacial development
Open accessAbstract
Background: Hyaluronan is a crucial glycosaminoglycan of the vertebrate embryonic extracellular matrix able to influence cell behaviour, both by assembling the pericellular matrices and by activating signal transducing receptors such as CD44. Results: We showed that the hyaluronan synthases, Has1 and Has2, and CD44 display a dynamic expression pattern during cranial neural crest cells (NCC) development. By knocking down Has1 and Has2 gene functions, we revealed that hyaluronan synthesized by Has1 and Has2 is necessary for the proper development of the visceral skeleton. Conclusions: The data suggest that hyaluronan helps to maintain the active migratory behaviour of cranial NCC, and that its presence around pre‐chondrogenic NCC is crucial for their survival. CD44 knock down also suggests that the role of hyaluronan in cranial NCC migration could be mediated, at least in part, by the activation of CD44. These findings contribute to the unveiling of the functional relation between NCC and their extracellular environment during craniofacial development. Developmental Dynamics 241:294–302, 2012. © 2011 Wiley Periodicals, Inc.
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HAS2 encodes hyaluronan synthase 2, a protein that plays an important role in embryonic development of branchial arches and cranial neural crest cells.
“which encodes hyaluronan synthase 2, a protein that plays an important role in embryonic development of branchial arches [6] and cranial neural crest cells (CNCCs) [7].”
From Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci (2023) · cites this paper as [7]
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References 48 · Cited by 33
Research works printed but not linked: 1
- Toole BP. 1991. Proteoglycans and hyalur- onan in morphogenesis and differentia- tion. In: Hay E, editor. Cell biology of extracellular matrix. New York: Plenum Press. p 305-341.
- Authors
- Casini, P., Nardi, I., & Ori, M.
- Affiliations
- University of Pisa (IT)
- Corresponding author
- Ori, Michela
- ORCID
- Ori, Michela
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2011-12-19
- Volume
- 241
- Issue
- 2
- Pages
- 294-302
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2141332147
- Cited by
- 33
- References
- 48
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Dynamics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
- Keywords
- hyaluronic acid, cranial neural crest cells, cell migration, craniofacial development, HAS1, HAS2, hyaluronan synthase, CD44, extracellular matrix, glycosaminoglycans
- MeSH terms
- Hyaluronan Synthases, Animals, Cell Movement, Hyaluronic Acid, Membrane Proteins, Neural Crest, Glucuronosyltransferase, Xenopus laevis, Glycosyltransferases, Craniofacial Abnormalities, Xenopus Proteins, Gene Knockdown Techniques
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