Heads‐up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells
Abstract
Fragile X syndrome (FXS) is the most common form of inherited mental retardation and is caused by the loss of function for Fragile X Mental Retardation Protein (FMRP), a selective RNA‐binding protein with a demonstrated role in the localized translation of target mRNAs at synapses. Several recent studies provide compelling evidence for a new role of FMRP in the development of the nervous system, during neurogenesis. Using a multi‐faceted approach and a variety of model systems ranging from cultured neurospheres and progenitor cells to in vivo Drosophila and mouse models these reports indicate that FMRP is required for neural stem and progenitor cell proliferation, differentiation, survival, as well as regulation of gene expression. Here we compare and contrast these recent reports and discuss the implications of FMRP's new role in embryonic and adult neurogenesis, including the development of novel therapeutic approaches to FXS and related neurological disorders such as autism. genesis 49:424–440,2011. © 2011 Wiley‐Liss, Inc.
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FMRP is necessary for the proliferation, differentiation, and survival of neural stem and progenitor cells.
“FMRP is also required for neural stem and progenitor cell proliferation, differentiation, and survival, suggesting additional mechanisms that could explain certain features of the disease (136).”
From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [136]
FMRP's role in neural stem and progenitor cells suggests additional mechanisms that could explain certain features of FXS.
“suggesting additional mechanisms that could explain certain features of the disease (136).”
From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [136]
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References 140 · Cited by 39
- Authors
- Callan, M. A., & Zarnescu, D. C.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Zarnescu, Daniela C.
- ORCID
- Zarnescu, Daniela C.
- Venue
- genesis
- Publisher
- Wiley
- Published
- 2011-05-31
- Volume
- 49
- Issue
- 6
- Pages
- 424-440
- ISSN
- 1526-954X (ISSN-L)
- 1526-968X
- OpenAlex
- W2157736128
- Cited by
- 39
- References
- 140
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 7
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- genesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM08569)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Keywords
- FMRP, fragile X syndrome, neural stem cells, neural progenitor cells, neurogenesis, RNA-binding proteins, neurospheres, Drosophila, mouse model, autism spectrum disorder, gene expression regulation, cell proliferation and differentiation
- MeSH terms
- Animals, Cell Differentiation, Cell Survival, Drosophila, Gene Expression Regulation, Humans, RNA, Messenger, Cell Proliferation, Mice, Fragile X Mental Retardation Protein, Fragile X Messenger Ribonucleoprotein 1, Neurogenesis, Neural Stem Cells
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