Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position Statement on Endomyocardial Biopsy
Open accessAbstract
Endomyocardial biopsy (EMB) is an invasive procedure, globally most often used for the monitoring of heart transplant (HTx) rejection. In addition, EMB can have an important complementary role to the clinical assessment in establishing the diagnosis of diverse cardiac disorders, including myocarditis, cardiomyopathies, drug-related cardiotoxicity, amyloidosis, other infiltrative and storage disorders, and cardiac tumours. Improvements in EMB equipment and the development of new techniques for the analysis of EMB samples have significantly improved diagnostic precision of EMB. The present document is the result of the Trilateral Cooperation Project between the Heart Failure Association of the European Society of Cardiology, the Heart Failure Society of America, and the Japanese Heart Failure Society. It represents an expert consensus aiming to provide a comprehensive, up-to-date perspective on EMB, with a focus on the following main issues: (i) an overview of the practical approach to EMB, (ii) an update on indications for EMB, (iii) a revised plan for HTx rejection surveillance, (iv) the impact of multimodality imaging on EMB, and (v) the current clinical practice in the worldwide use of EMB.
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Complication rates of EMB can be higher (8.9%) in lower volume centers.
“complication rates can be higher (8.9%) in lower volume centers.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [240]
EMB remains the gold standard for diagnosing acute myocarditis.
“EMB remains the gold standard for diagnosing acute myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [240]
Cites
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“62,63 Electroanatomic voltage mapping guidance may be useful, as suggested by a cohort of patients with unexplained atrioventricular block, where a comprehensive evaluation, including electroanatomic voltage mapping guided-EMB, demonstrated cardiac sarcoidosis in 34%.”
BackgroundKusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000628 · Cited by 603 · see citing works
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Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Heart Rhythm · doi:10.1016/j.hrthm.2018.10.037 · Cited by 131 · see citing works
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Baritussio, A., Schiavo, A., Basso, C., Giordani, A. S., Cheng, C., Pontara, E., Cattini, M. G., Bison, E., Gallo, N., De Gaspari, M., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2496 · Cited by 90 · see citing works
Self-citationAutoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
- Authors
- Seferović, P. M., Tsutsui, H., McNamara, D. M., Ristić, A. D., Basso, C., Bozkurt, B., Cooper, L. T., Filippatos, G., Ide, T., Inomata, T., Klingel, K., Linhart, A., Lyon, A. R., Mehra, M. R., Polovina, M., Milinković, I., Nakamura, K., Anker, S. D., Veljić, I., Ohtani, T., Okumura, T., Thum, T., Tschöpe, C., Rosano, G., Coats, A. J. S., & Starling, R. C.
- Affiliations
- Serbian Academy of Sciences and Arts , Belgrade ,
- Kyushu University (JP)
- University of Pittsburgh Medical Center (US)
- University of Belgrade (RS)
- University of Padua (IT)
- Michael E. DeBakey VA Medical Center (US)
- Mayo Clinic (US)
- National and Kapodistrian University of Athens (GR)
- Kitasato Institute Hospital (JP)
- Universitätsklinikum Tübingen (DE)
- Charles University (CZ)
- Royal Brompton Hospital (GB)
- Brigham and Women's Hospital (US)
- Okayama University (JP)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- Univerzitetski Klinički Centar Srbije (RS)
- The University of Osaka (JP)
- Nagoya University (JP)
- Medizinische Hochschule Hannover (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Warwick (GB)
- Cleveland Clinic (US)
- ORCID
- Tsutsui, Hiroyuki
- McNamara, Dennis M.
- Ristić, Arsen D.
- Basso, Cristina
- Bozkurt, Biykem
- Cooper, Leslie T.
- Filippatos, Gerasimos
- Ide, Tomomi
- Inomata, Takayuki
- Klingel, Karin
- Linhart, Aleš
- Lyon, Alexander R.
- Mehra, Mandeep R.
- Polovina, Marija
- Milinković, Ivan
- Nakamura, Kazufumi
- Anker, Stefan D.
- Veljić, Ivana
- Ohtani, Tomohito
- Okumura, Takahiro
- Thum, Thomas
- Tschöpe, Carsten
- Rosano, Giuseppe
- Coats, Andrew J.S.
- Starling, Randall C.
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-05-19
- Volume
- 23
- Issue
- 6
- Pages
- 854-871
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W3163194516
- Cited by
- 219
- References
- 5
- Citations by year
- 2026: 28 · 2025: 44 · 2024: 50 · 2023: 47 · 2022: 39 · 2021: 11
- FWCI
- 24.62
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-03-17)
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- endomyocardial biopsy, heart transplantation, myocarditis, cardiomyopathy, drug-induced cardiotoxicity, cardiac amyloidosis, infiltrative cardiomyopathy, cardiac tumor, multimodality cardiac imaging, biopsy indications, heart failure
- MeSH terms
- Biopsy, Endocardium, Heart Failure, Humans, Japan, Myocardium, Heart Transplantation
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