The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Two subsets of rat T lymphocytes defined with monoclonal antibodies
Abstract
A new monoclonal mouse antibody that recognizes a subset of rat peripheral T cells has been prepared by immunizing mice with rat thymocyte glycoprotein. This antibody, designated MRC OX 8, labels all peripheral T cells that are unlabeled by the previously described W3/25 monoclonal antibody. No peripheral T cells were found that bound both antibodies, but, in contrast, 90% of thymocytes were doubly labeled. Thoracic duct lymphocytes of congenitally athymic nude rats were not labeled by either antibody, but the spleens of such animals contained both W3/25+ cells and MRC OX 8+ cells. These splenocyte subpopulations did not overlap. Using the fluorescence‐activated cell sorter to isolate cells binding MRC OX 8 antibody, the phenotype of T cells mediating various T cell functions was established. Combining the present results with those published previously, it is shown that the cells providing help for antibody responses and those mediating graft‐vs. ‐host reactions are phenotypically W3/25+ MRC OX 8−. On the other hand, parental T cells that suppress antibody formation in F 1 hosts were identified as W3/25− MRC OX 8+. The relationship between the rat T cell subsets defined by these antibodies and those in the mouse identified by the Ly series of alloantibodies is discussed and a comparison made between the rat W3/25+ subset and a recently identified human T cell subset.
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Citations
Cites
Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion
Köhler, G., & Milstein, C. (1976) · European Journal of Immunology · doi:10.1002/eji.1830060713 · Cited by 1,922
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Self-citationIdentification of Ia glycoproteins in rat thymus and purification from rat spleen
McMaster, W. R., & Williams, A. F. (1979) · European Journal of Immunology · doi:10.1002/eji.1830090603 · Cited by 678
Self-citationThe kinetics of antibody binding to membrane antigens in solution and at the cell surface
Mason, D. W., & Williams, A. F. (1980) · Biochemical Journal · doi:10.1042/bj1870001 · Cited by 567
Self-citationSunderland, C. A., McMaster, W. R., & Williams, A. F. (1979) · European Journal of Immunology · doi:10.1002/eji.1830090212 · Cited by 277
Self-citationThe binding of anti‐immunoglobulin antibodies to rat thymocytes and thoracic duct lymphocytes
Jensenius, J. C., & Williams, A. F. (1974) · European Journal of Immunology · doi:10.1002/eji.1830040207 · Cited by 202
Self-citationWebb, M., MASON, D. W., & Williams, A. (1979) · Nature · doi:10.1038/282841a0 · Cited by 93
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Cited by
Astrocytes present myelin basic protein to encephalitogenic T-cell lines
Fontana, A., Fierz, W., & Wekerle, H. (1984) · Nature · doi:10.1038/307273a0 · Cited by 771
Dhabhar, F. S., Malarkey, W. B., Neri, E., & McEwen, B. S. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.008 · Cited by 589
“, 1984), PE-conjugated W3/25, as a marker for helper T lymphocytes (Brideau et al., 1980), PE-Cy5-conjugated OX-8, as a marker for cytolytic T cells (CTL) (Barclay, 1981; Johnson et al.”
BackgroundMethodHünig, T., Wallny, H. J., Hartley, J. K., Lawetzky, A., & Tiefenthaler, G. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.1.73 · Cited by 451
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Self-citationIntracerebral inflammatory response to experimental brain contusion
Holmin, S., Mathiesen, T., Shetye, J., & Biberfeld, P. (1995) · Acta Neurochirurgica · doi:10.1007/bf01404857 · Cited by 277
Metadata
- Authors
- Brideau, R. J., Carter, P. B., McMaster, W. R., Mason, D. W., & Williams, A. F.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1980-08
- Volume
- 10
- Issue
- 8
- Pages
- 609-615
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2140892076
- Cited by
- 667
- References
- 7
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brideau, R. J., Carter, P. B., McMaster, W. R., Mason, D. W., & Williams, A. F. (1980). Two subsets of rat T lymphocytes defined with monoclonal antibodies. European Journal of Immunology. https://doi.org/10.1002/eji.1830100807
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