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MRC OX‐19: A monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses
Abstract
A mouse monoclonal antibody, designated MRC OX‐19, has been prepared that binds to virtually all rat thymocytes, T lymphocytes and a maximum of 2% B lymphocytes. Immunoperoxidase studies on tissue sections showed no reactivity with nonlymphoid cells in intestine, thymus, spleen and lymph node. The antigen recognized by MRC OX‐19 antibody was identified by metabolic and cell surface labeling of thymocytes followed by immunoprecipitation and sodium dodecyl sulfate gel elec‐trophoresis. It is a surface glycoprotein of M r = 69000. When included in in vitro assays for T cell functions, MRC OX‐19 increased proliferation stimulated by allogeneic spleen cells or the lectins phytohemagglutinin and concanavalin A. The antibody itself was not mitogenic and its stimulatory effect could be correlated with an increase in interleukin 2 production. Taken together the data suggest that MRC OX‐19 could be the equivalent of mouse Ly‐1 antigen and human T1 antigen.
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Cited by
Dhabhar, F. S., Malarkey, W. B., Neri, E., & McEwen, B. S. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.008 · Cited by 589
“Briefly, lymphocyte subsets were defined using 3-color panels consisting of the following monoclonal antibodies (Harlan, Indianapolis, IN): In the first panel we used FITC-conjugated OX-19 as a pan-T cell marker (Dallman et al., 1984), PE-conjugated W3/25, as a marker for helper T lymphocytes (Brideau et al.”
MethodHughes, P. M., Botham, M. S., Frentzel, S., Mir, A., & Perry, V. H. (2002) · Glia · doi:10.1002/glia.10037 · Cited by 252
Differential Expression of MHC Class II Antigen in the Contused Rat Spinal Cord
POPOVICH, P. G., STREIT, W. J., & STOKES, B. T. (1993) · Journal of Neurotrauma · doi:10.1089/neu.1993.10.37 · Cited by 42
Metadata
- Authors
- Dallman, M. J., Thomas, M. L., & Green, J. R.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1984-01
- Volume
- 14
- Issue
- 3
- Pages
- 260-267
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2062006560
- Cited by
- 304
- References
- 0
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dallman, M. J., Thomas, M. L., & Green, J. R. (1984). MRC OX‐19: A monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses. European Journal of Immunology. https://doi.org/10.1002/eji.1830140311
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