The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality
Abstract
The in vivo efficacy of human recombinant soluble tumor necrosis factor (TNF) receptor protein to prevent and to treat lipopolysaccharide (LPS)‐induced lethal toxicity in D‐galactosamine‐treated mice was investigated. Chimeric proteins of the receptor extracellular domains fused to the hinge region of human IgG3 were expressed in myeloma cells (rsTNFR‐hγ3). The fusion proteins had a disulfide‐bonded dimeric structure. Upon intravenous injection, their serum concentration decreased relatively slowly after an initial phase of rapid elimination. D‐galactosamine‐sensitized mice were fully protected from the toxic effects of LPS, if the animal were pretreated with rsTNFR‐hγ3 at 20 μg/animal. Partial protection was seen at significantly lower doses and when rsTNFR‐hγ3 was given up to 3 h after LPS.
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Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677
Cited by
Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?
Feldmann, M., & Maini, R. N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.163 · Cited by 1,257
The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder
Maes, M., & Carvalho, A. F. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1016-x · Cited by 306
Metadata
- Authors
- Lesslauer, W., Tabuchi, H., Gentz, R., Brockhaus, M., Schlaeger, E. J., Grau, G., Piguet, P. F., Pointaire, P., Vassalli, P., & Loetscher, H.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1991-11
- Volume
- 21
- Issue
- 11
- Pages
- 2883-2886
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2096824527
- Cited by
- 237
- References
- 3
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality. https://app.cochat.ai/papers/10.1002/eji.1830211134
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- Lesslauer, W., Tabuchi, H., Gentz, R., Brockhaus, M., Schlaeger, E. J., Grau, G., Piguet, P. F., Pointaire, P., Vassalli, P., & Loetscher, H. (1991). Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality. European Journal of Immunology. https://doi.org/10.1002/eji.1830211134
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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