The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages
Abstract
Inbred strains of mice differ considerably in their innate resistance to leishmanial infection. BALB/c mice are highly susceptible to cutaneous leishmaniasis caused by Leishmania major, whereas CBA mice are resistant. We now show that this resistance correlates with the ability of macrophages to synthesize nitric oxide (NO) following activation with interferon‐γ or tumor necrosis factor α. Furthermore, the larger amounts of NO generated by resistant macrophages are related to higher levels of NO synthase activity, a difference which is not attributable to the number or the affinity of the receptors for interferon‐γ on these cells. The level of NO synthesis by activated macrophages was also correlated to the resistance in a number of other inbred mouse strains tested; macrophages from the resistant B10.S, C57BL and C3H mice produced significantly higher levels of NO than the macrophages from the susceptible BALB.b and DBA/2 mice.
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Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Self-citationLiew, F. Y., Li, Y., & Millott, S. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.12.4306 · Cited by 522
Self-citationBogdan, C., Moll, H., Solbach, W., & Röllinghoff, M. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200528 · Cited by 183
Cited by
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
The Central Role of CD4+ T Cells in the Antitumor Immune Response
Hung, K., Hayashi, R., Lafond-Walker, A., Lowenstein, C., Pardoll, D., & Levitsky, H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2357 · Cited by 1,345
Nitric oxide in immunity and inflammation
Coleman, J. W. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00086-8 · Cited by 945
Vespa, G. N., Cunha, F. Q., & Silva, J. S. (1994) · Infection and Immunity · doi:10.1128/iai.62.11.5177-5182.1994 · Cited by 398
Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania
Lima-Junior, D. S., Costa, D. L., Carregaro, V., Cunha, L. D., Silva, A. L. N., Mineo, T. W. P., Gutierrez, F. R. S., Bellio, M., Bortoluci, K. R., Flavell, R. A., et al. (2013) · Nature Medicine · doi:10.1038/nm.3221 · Cited by 360
Metadata
- Authors
- Liew, F. Y., Li, Y., Moss, D., Parkinson, C., Rogers, M. V., & Moncada, S.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1991-12
- Volume
- 21
- Issue
- 12
- Pages
- 3009-3014
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1983667471
- Cited by
- 199
- References
- 3
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liew, F. Y., Li, Y., Moss, D., Parkinson, C., Rogers, M. V., & Moncada, S. (1991). Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages. European Journal of Immunology. https://doi.org/10.1002/eji.1830211216
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