Induction of virus‐specific cytotoxic T lymphocytes in vivo by liposome‐entrapped mRNA

Martinon, Frédéric, Krishnan, Sivadasan, Lenzen, Gerlinde, Magné, Rémy, Gomard, Elisabeth, Guillet, Jean‐Gérard, Lévy, Jean‐Paul, Meulien, Pierre·1993·European Journal of Immunology

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    Jeffrey B. Ulmer, John Donnelly, Margaret A. Liu · 1994 · Springer eBooks
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