Co‐localization of the neonatal Fcγ receptor and IgG in human placental term syncytiotrophoblasts
Abstract
Transfer of maternal IgG through the human placenta furnishes the newborn with passive immunity to a number of infectious agents. The exact mechanism of this transfer is still unknown, but it is agreed that it involves active receptor-mediated transport. The neonatal Fc receptor is a major histocompatibility complex class I-like receptor originally identified in the intestines of newborn rodents. A similar receptor has recently been detected in human placental syncytiotrophoblasts. Using multilabeling fluorescence immunohistochemistry and confocal laser scanning microscopy, we found that the neonatal Fc receptor co-localizes with IgG and beta 2-microglobulin in granules of human placental syncytiotrophoblast. The Fc receptor is not detected on syncytiotrophoblast apical plasma membrane. Localization to the outermost cellular barrier between the fetal and maternal blood further strengthens the role of the Fc receptor in transplacental transport of IgG.
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Various studies using immunohistochemical staining of placental sections with anti-FcRn antibodies have shown a mix of some or no FcRn expression in fetal endothelium.
“Various studies using immunohistochemical staining of placental sections with anti-FcRn antibodies have shown a mix of some (61, 62) or no (36).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [62]
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Raghavan, M., Bonagura, V. R., Morrison, S. L., & Bjorkman, P. J. (1995) · Biochemistry · doi:10.1021/bi00045a005 · Cited by 317 · see citing works
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Placental transport of immunoglobulin G
Simister, N. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00334-7 · Cited by 783 · see citing works
Wilcox, C. R., Holder, B., & Jones, C. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01294 · Cited by 200 · see citing works
“Various studies using immunohistochemical staining of placental sections with anti-FcRn antibodies have shown a mix of some (61, 62) or no (36).”
- Authors
- Kristoffersen, E. K., & Matre, R.
- Affiliations
- University of Bergen (NO)
- Corresponding author
- Kristoffersen, Einar K.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 26
- Issue
- 7
- Pages
- 1668-1671
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2010213634
- Cited by
- 90
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- neonatal Fc receptor, IgG, syncytiotrophoblast, placenta, transplacental IgG transfer, passive immunity, beta2-microglobulin, receptor-mediated transport
- MeSH terms
- beta 2-Microglobulin, Cesarean Section, Female, Humans, Immunoglobulin G, Pregnancy, Trophoblasts, Receptors, IgG, Microscopy, Confocal
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