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Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells
Abstract
Lymphocyte activation gene 3 (LAG-3/CD223) is a CD4 homolog known to be selectively expressed in activated T and NK cells. It is thought to have a negative regulatory function in T cells. With the help of new monoclonal antibodies against mouse LAG-3, we show that LAG-3 surface expression is not limited to activated T and NK cells but is also found on activated B cells. Induction of B cell surface expression is T cell dependent and mediated by a soluble factor. The majority of LAG-3 on B cell surface is endogenously produced, even though soluble LAG-3 is present in the culture supernatants and can be passively absorbed. As B cells express LAG-3 in a T cell dependent manner and not when activated by Toll-like-receptor agonists alone, we propose LAG-3 as a new marker of T cell induced B cell activation.
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Cites
Cutting Edge: Molecular Analysis of the Negative Regulatory Function of Lymphocyte Activation Gene-3
Workman, C. J., Dugger, K. J., & Vignali, D. A. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5392 · Cited by 389
Workman, C. J., Cauley, L. S., Kim, I.-J., Blackman, M. A., Woodland, D. L., & Vignali, D. A. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5450 · Cited by 351
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Metadata
- Authors
- Kisielow, M., Kisielow, J., Capoferri-Sollami, G., & Karjalainen, K.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2005-07
- Volume
- 35
- Issue
- 7
- Pages
- 2081-2088
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2091794422
- Cited by
- 271
- References
- 2
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kisielow, M., Kisielow, J., Capoferri-Sollami, G., & Karjalainen, K. (2005). Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells. European Journal of Immunology. https://doi.org/10.1002/eji.200526090
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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