The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Cell wall glycosphingolipids ofSphingomonas paucimobilisare CD1d-specific ligands for NKT cells
Open accessAbstract
The current consensus on characterization of NKT cells is based on their reactivity to the synthetic glycolipid, alpha-galactosylceramide (alpha-GalCer) in a CD1d-dependent manner. Because of the limited availability of alpha-GalCer, there is a constant search for CD1d-presented ligands that activate NKT cells. The alpha-anomericity of the carbohydrate is considered to be an important requisite for the CD1d-specific activation of NKT cells. The gram-negative, lipopolysaccharide-free bacterium Sphingomonas paucimobilis is known to contain glycosphingolipids (GSL) with alpha-anomeric sugars attached to the lipid chain. Here, we report that GSL extracted from this bacterium are able to stimulate NKT cells in a CD1d-specific manner. In addition, soluble CD1d-Ig dimers loaded with this lipid extract specifically bind to NKT cells (but not conventional T cells). Further studies on the S. paucimobilis GSL could potentially lead to other natural sources of CD1d-specific ligands useful for NKT cell analyses and aimed at identifying novel therapies for a variety of disease states.
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Cited by
Cohen, N. R., Tatituri, R. V. V., Rivera, A., Watts, G. F. M., Kim, E. Y., Chiba, A., Fuchs, B. B., Mylonakis, E., Besra, G. S., Levitz, S. M., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.09.011 · Cited by 115
Recognition of microbial glycolipids by natural killer T cells
Zajonc, D. M., & Girardi, E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00400 · Cited by 76
Pei, B., Vela, J. L., Zajonc, D., & Kronenberg, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06435.x · Cited by 33
Metadata
- Authors
- Sriram, V., Du, W., Gervay-Hague, J., & Brutkiewicz, R. R.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2005-06
- Volume
- 35
- Issue
- 6
- Pages
- 1692-1701
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2093041058
- Cited by
- 309
- References
- 42
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sriram, V., Du, W., Gervay-Hague, J., & Brutkiewicz, R. R. (2005). Cell wall glycosphingolipids ofSphingomonas paucimobilisare CD1d-specific ligands for NKT cells. European Journal of Immunology. https://doi.org/10.1002/eji.200526157
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