The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells
Open accessAbstract
IL‐23 is regarded as a major pro‐inflammatory mediator in autoimmune disease, a role which until recently was ascribed to its related cytokine IL‐12. IL‐23, an IL‐12p40/p19 heterodimeric protein, binds to IL‐12Rβ1/IL‐23R receptor complexes. Mice deficient for p19, p40 or IL‐12Rβ1 are resistant to experimental autoimmune encephalomyelitis or collagen‐induced arthritis. Paradoxically, however, IL‐12Rβ2‐ and IL‐12p35‐deficient mice show remarkable increases in disease susceptibility, suggesting divergent roles of IL‐23 and IL‐12 in modulating inflammatory processes. IL‐23 induces IL‐17, which mediates inflammation and tissue remodeling, but the role of IL‐12 in this respect remains unidentified. We investigated the roles of exogenous (recombinant) and endogenous (macrophage‐derived) IL‐12 and IL‐23, on IL‐17‐induction in human T‐cells. IL‐23 enhanced IL‐17 secretion, as did IL‐2, IL‐15, IL‐18 and IL‐21. In contrast, IL‐12 mediated specific inhibition of IL‐17 production. These data support the role of IL‐23 in inflammation through stimulating IL‐17 production by T lymphocytes, and importantly indicate a novel regulatory function for IL‐12 by specifically suppressing IL‐17 secretion. These data therefore extend previous reports that had indicated unique functions for IL‐23 and IL‐12 due to distinct receptor expression and signal transduction complexes, and provide novel insights into the regulation of immunity, inflammation and immunopathology.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
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Cited by
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
Krausgruber, T., Blazek, K., Smallie, T., Alzabin, S., Lockstone, H., Sahgal, N., Hussell, T., Feldmann, M., & Udalova, I. A. (2011) · Nature Immunology · doi:10.1038/ni.1990 · Cited by 1,306
Afzali, B., Lombardi, G., Lechler, R. I., & Lord, G. M. (2007) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2007.03356.x · Cited by 762
Primary Biliary Cirrhosis Associated with HLA, IL12A, and IL12RB2 Variants
Hirschfield, G. M., Liu, X., Xu, C., Lu, Y., Xie, G., Lu, Y., Gu, X., Walker, E. J., Jing, K., Juran, B. D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810440 · Cited by 594
Metadata
- Authors
- Hoeve, M. A., Savage, N. D. L., de Boer, T., Langenberg, D. M. L., de Waal Malefyt, R., Ottenhoff, T. H. M., & Verreck, F. A. W.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2006-02-28
- Volume
- 36
- Issue
- 3
- Pages
- 661-670
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2149264611
- Cited by
- 245
- References
- 7
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells. https://app.cochat.ai/papers/10.1002/eji.200535239
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- Hoeve, M. A., Savage, N. D. L., de Boer, T., Langenberg, D. M. L., de Waal Malefyt, R., Ottenhoff, T. H. M., & Verreck, F. A. W. (2006). Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells. European Journal of Immunology. https://doi.org/10.1002/eji.200535239
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