The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
IL‐33‐activated dendritic cells are critical for allergic airway inflammation
Abstract
IL‐33, a new member of the IL‐1 family cytokine, is involved in Th2‐type responses in a wide range of diseases and signals through the ST2 receptor expressed on many immune cells. Since the effects of IL‐33 on DCs remain controversial, we investigated the ability of IL‐33 to modulate DC functions in vitro and in vivo. Here, we report that IL‐33 activates myeloid DCs to produce IL‐6, IL‐1b, TNF, CCL17 and to express high levels of CD40, CD80 OX40L and CCR7. Importantly, IL‐33‐activated DCs prime naive lymphocytes to produce the Th2 cytokines IL‐5 and IL‐13, but not IL‐4. In vivo, IL‐33 exposure induces DC recruitment and activation in the lung. Using an OVA‐induced allergic lung inflammation model, we demonstrate that the reduced airway inflammation in ST2‐deficient mice correlates with the failure in DC activation and migration to the draining LN. Finally, we show that adoptive transfer of IL‐33‐activated DCs exacerbates lung inflammation in a DC‐driven model of allergic airway inflammation. These data demonstrate for the first time that IL‐33 activates DCs during antigen presentation and thereby drives a Th2‐type response in allergic lung inflammation .
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Cites
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The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
Cayrol, C., & Girard, J.-P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812690106 · Cited by 707
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Lüthi, A. U., Cullen, S. P., McNeela, E. A., Duriez, P. J., Afonina, I. S., Sheridan, C., Brumatti, G., Taylor, R. C., Kersse, K., Vandenabeele, P., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.007 · Cited by 677
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Cited by
The interleukin-1 family: back to the future
Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945
“IL-33-activated dendritic cells (DCs) favor polarization of Th2 cells (Besnard et al., 2011).”
Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
Mantovani, A., Dinarello, C. A., Molgora, M., & Garlanda, C. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.012 · Cited by 1,046
Barrier Epithelial Cells and the Control of Type 2 Immunity
Hammad, H., & Lambrecht, B. N. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.007 · Cited by 847
TH2 cell development and function
Walker, J. A., & McKenzie, A. N. J. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.118 · Cited by 632
Metadata
- Authors
- Besnard, A., Togbe, D., Guillou, N., Erard, F., Quesniaux, V., & Ryffel, B.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2011-05-25
- Volume
- 41
- Issue
- 6
- Pages
- 1675-1686
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1975075371
- Cited by
- 331
- References
- 8
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Besnard, A., Togbe, D., Guillou, N., Erard, F., Quesniaux, V., & Ryffel, B. (2011). IL‐33‐activated dendritic cells are critical for allergic airway inflammation. European Journal of Immunology. https://doi.org/10.1002/eji.201041033
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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