Functional development of γδ T cells
Open accessAbstract
The thymus generates T cells that are generally functionally immature and thus require peripheral activation for differentiation into effector lymphocytes. Notable exceptions to this rule are murine γδ T cells, many of which have been shown to acquire their functional potential during thymic development from late embryonic stages. Here, we review the underlying ontogenic processes and molecular differentiation mechanisms of murine γδ T cells, focusing on the transcriptional control of IFN‐γ and IL‐17 expression. We propose that functional commitment of γδ T cells occurs in “developmental windows” defined by the molecular composition of the thymic microenvironment, such as T‐cell receptor (TCR), TCR coreceptor ligands, and cytokines. We further discuss the similarities and particularities of functional development of γδ T cells in mice and humans, while highlighting some key unresolved issues for future investigation.
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Current views in the field suggest that the functional potential of mouse γδ T cells is related to the use of Vγ, while the functional potential of humans is related to the use of Vδ.
“Current views in the field suggest that the functional potential of mouse γδ T cells is related to the use of Vγ, while the functional potential of humans is related to the use of Vδ (26).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [26]
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- C 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.eji-journal.eu 15214141, 2013, 8, · DOI
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Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells
Benakis, C., Brea, D., Caballero, S., Faraco, G., Moore, J., Murphy, M., Sita, G., Racchumi, G., Ling, L., Pamer, E. G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4068 · Cited by 1,114 · see citing works
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works
Self-citationComparing Mouse and Human Tissue-Resident γδ T Cells
Qu, G., Wang, S., Zhou, Z., Jiang, D., Liao, A., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.891687 · Cited by 87 · see citing works
- Authors
- Prinz, I., Silva‐Santos, B., & Pennington, D. J.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- University of Lisbon (PT)
- Queen Mary University of London (GB)
- Corresponding author
- Prinz, Immo
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2013-08
- Volume
- 43
- Issue
- 8
- Pages
- 1988-1994
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1852098389
- Cited by
- 205
- References
- 1
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 10 · 2023: 18 · 2022: 21 · 2021: 24 · 2020: 19 · 2019: 13 · 2018: 13 · 2017: 18 · 2016: 13 · 2015: 16 · 2014: 13 · 2013: 1 · 2012: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- γδ T cells, thymus development, functional differentiation, interferon-gamma, IL-17, transcriptional regulation, thymic microenvironment, developmental windows
- MeSH terms
- Animals, Cell Differentiation, Humans, Interferon-gamma, Thymus Gland, Transcription, Genetic, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, CD8-Positive T-Lymphocytes, Cell Lineage, Interleukin-17, Mice
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