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Cited by 39T-cell and B-cell ImmunologyTuberculosis Research and EpidemiologyImmune responses and vaccinations

Th17‐related cytokines contribute to recall‐like expansion/effector function of HMBPP‐specific Vγ2Vδ2 T cells after Mycobacterium tuberculosis infection or vaccination

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Shen, Hongbo, Wang, Yunqi, Chen, Crystal Y., Frencher, James, Huang, Dan, Yang, Enzhuo, Ryan‐Payseur, Bridgett, Chen, Zheng W.·2015·European Journal of Immunology
DOI 10.1002/eji.201444635PMC PMC4916493
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Abstract

Whether cytokines can influence the adaptive immune response by antigen‐specific γδ T cells during infections or vaccinations remains unknown. We previously demonstrated that, during BCG/Mycobacterium tuberculosis (Mtb) infections, Th17‐related cytokines markedly upregulated when phosphoantigen‐specific Vγ2Vδ2 T cells expanded. In this study, we examined the involvement of Th17‐related cytokines in the recall‐like responses of Vγ2Vδ2 T cells following Mtb infection or vaccination against TB. Treatment with IL‐17A/IL‐17F or IL‐22 expanded phosphoantigen 4‐hydroxy‐3‐methyl‐but‐enyl pyrophosphate (HMBPP)‐stimulated Vγ2Vδ2 T cells from BCG‐vaccinated macaques but not from naïve animals, and IL‐23 induced greater expansion than the other Th17‐related cytokines. Consistently, Mtb infection of macaques also enhanced the ability of IL‐17/IL‐22 or IL‐23 to expand HMBPP‐stimulated Vγ2Vδ2 T cells. When evaluating IL‐23 signaling as a prototype, we found that HMBPP/IL‐23‐expanded Vγ2Vδ2 T cells from macaques infected with Mtb or vaccinated with BCG or Listeria ΔactA prfA*‐ESAT6/Ag85B produced IL‐17, IL‐22, IL‐2, and IFN‐γ. Interestingly, HMBPP/IL‐23‐induced production of IFN‐γ in turn facilitated IL‐23‐induced expansion of HMBPP‐activated Vγ2Vδ2 T cells. Furthermore, HMBPP/IL‐23‐induced proliferation of Vγ2Vδ2 T cells appeared to require APC contact and involve the conventional and novel protein kinase C signaling pathways. These findings suggest that Th17‐related cytokines can contribute to recall‐like expansion and effector function of Ag‐specific γδ T cells after infection or vaccination.

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  • When lung infection occurs, Vγ1+, Vγ4+, and Vγ6+ T cells proliferate in the lung, and Vγ4+ γδ T cells secrete CXC chemokine ligand 2 (CXCL2; also known as MIP2) and TNF to promote neutrophil recruitment.

    “When lung infection occurs, Vγ1+, Vγ4+, and Vγ6+ T cells proliferate in the lung, and Vγ4+ γδ T cells secrete CXC chemokine ligand 2 (CXCL2; also known as MIP2) and TNF to promote neutrophil recruitment (41).”

    From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [41]

    The Introduction reports expansion of Vγ2Vδ2 T cells in lungs during mycobacterial infection, not proliferation of Vγ1+, Vγ4+, or Vγ6+ cells. Searches for those subsets and for CXCL2/MIP2, TNF, and neutrophil recruitment found no passage in our copy supporting the attributed mechanism; the Introduction mentions only general effects of IL-17 on neutrophils. Page numbers were not available in our copy. (LLM, conf=0.73)

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Authors
Shen, H., Wang, Y., Chen, C. Y., Frencher, J., Huang, D., Yang, E., Ryan‐Payseur, B., & Chen, Z. W.
Affiliations
  • Chinese Academy of Sciences (CN)
  • University of North Carolina at Chapel Hill (US)
  • University of Illinois Chicago (US)
  • Department of Microbiology and Immunology Center for Primate Biomedical Research University of Illinois College of Medicine Chicago IL USA
Corresponding author
  • Shen, Hongbo
  • Chen, Zheng W.
ORCID
Venue
European Journal of Immunology
Publisher
Wiley
Published
2015-02
Volume
45
Issue
2
Pages
442-451
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
DOI
10.1002/eji.201444635
PMC
PMC4916493
OpenAlex
W1506337752
Cited by
39
References
1
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 5 · 2014: 1
FWCI
1.22
Type
journal article
Language
en
Update notices
correction (2019-11-13)
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8 d)
Locations
  • European Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (R01 RR13601)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
Vγ9Vδ2 T cells, γδ T cells, IL-23, IL-17, IL-22, HMBPP, phosphoantigens, Mycobacterium tuberculosis, BCG vaccination, effector function, interferon-gamma, protein kinase C signaling, macaque
MeSH terms
Interleukin-22, Animals, Bacterial Vaccines, Cells, Cultured, Interferon-gamma, Interleukin-2, Interleukins, Listeria, Macaca fascicularis, Mycobacterium bovis, Mycobacterium tuberculosis, Organophosphates, Recombinant Proteins, Tuberculosis, Vaccination, Gene Expression, Receptors, Antigen, T-Cell, gamma-delta, Interleukin-17, Cell Proliferation, Interleukin-23, Th17 Cells

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