Blockade of PD‐1 or p38 MAP kinase signaling enhances senescent human CD8+ T‐cell proliferation by distinct pathways

Henson, Sian M., Macaulay, Richard, Riddell, Natalie E., Nunn, Craig J., Akbar, Arne N.·2015·European Journal of Immunology

Cited by (147)

Items 101–147 of 147

  1. Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity
    Ignacio Juárez, Shi Su, Zachary T. Herbert, John Ross Teijaro, Vaishali R. Moulton · 2022 · Frontiers in Immunology
  2. Senescent CD4+ T cells and autoimmune diseases: mechanisms and therapeutic prospects
    Yue Hu, Liting He, Hai Long · 2025 · Autoimmunity Reviews
  3. Transcriptome-based measurement of CD8+ T cell age and its applications
    Nan‐ping Weng · 2023 · Trends in Immunology
  4. CD8+ TEMRAs in severe asthma associate with asthma symptom duration and escape proliferation arrest
    Richard Paul Ramonell, Timothy B. Oriss, Jessica Partyka, Sagar Laxman Kale, Nicole R. Brandon, Mark A. Ross, Marc C. Gauthier, Molin Yue, Taylor J. Nee, Sudipta Das et al. · 2025 · JCI Insight
  5. Aged T cells and cardiovascular disease
    Min Kyung Jung, Eui‐Cheol Shin · 2017 · Cellular and Molecular Immunology
  6. Markers of immunosenescence in CMV seropositive healthy elderly adults
    Ivón Johanna Rodríguez, Carlos Parra-López · 2025 · Frontiers in Aging
  7. MK2 drives progression of pancreas and colon cancers by suppressing CD8+ T cell cytotoxic function and is a potential immunotherapy target
    Damian Jacenik, Eric J. Lebish, Ellen J. Beswick · 2023 · Frontiers in Immunology
  8. Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD
    Won Dong Kim, Don D. Sin · 2024 · COPD Journal of Chronic Obstructive Pulmonary Disease
  9. Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes
    Zhang Li, Yang Luo, Haili Shen · 2025 · Journal of Orthopaedic Surgery and Research
  10. Immunosenescence and Cancer Immunotherapy at Old Age: Basics
    Tamàs Fülöp, J. M. Witkowski, Katsuiku Hirokawa, Anis Larbi, Graham Pawelec · 2018 · Springer eBooks
  11. Immunosenescence and Cancer Immunotherapy at Old Age: Basics
    Tamàs Fülöp, Jacek Maciej Witkowski, K. Hirokawa, Anis Larbi, Graham Pawelec · 2020 · Springer eBooks
  12. Charlson syndrome index predicted survival in pancreatic cancer patients received immunotherapy
    Nan Zhang, Shiyun Chen, Yue Shi, Zhikuan Wang, Ru Jia, Guanghai Dai · 2025 · Frontiers in Immunology
  13. Multiplex engineering and multifunction T cells for precise and effective immunotherapies
    Leila Jafarzadeh, Ali Smaani, Jean‐Sébastien Delisle · 2025 · Frontiers in Immunology
  14. From Inflamm-Aging to Immunosenescence
    Tamàs Fülöp, Jacek Maciej Witkowski, Alan Arthur Cohen, Gilles Dupuis, Katsuiku Hirokawa, Anis Larbi · 2019 · Cambridge University Press eBooks
  15. T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives
    Suqing Zhou, Lian Jian, Hui Chen, Huan Yin, Fanghan Ji, Ming Yang, Haijing Wu · 2026 · Clinical Reviews in Allergy & Immunology
  16. T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy
    Lauren van den Broecke, Arne Van der Vreken, Fenja Watté, Fien Meeus, Kim De Veirman, Karine Breckpot, Elke De Bruyne, Eline Menu · 2026 · Signal Transduction and Targeted Therapy
  17. Senescent T Cells: The Silent Culprit in Acute Myeloid Leukemia Progression?
    Xiaolan Zhang, Lingbo Liu · 2024 · International Journal of Molecular Sciences
  18. When wrinkles appear on the immune system can it be reversed?
    Hiba Sibaii, Salwa Refat El-Zayat, M. Khalil · 2020 · European Cytokine Network
  19. Physical activity modifies the metabolic profile of CD4+ and CD8+ T cell subtypes at rest and upon activation in older adults
    Edward Withnall, Jon Hazeldine, Alba Llibre, Niharika Arora Duggal, Janet M. Lord, Amanda Veiga Sardeli · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Immune checkpoint inhibition in the context of aging
    Constantin N. Baxevanis, Ourania Tsitsilonis · 2025 · Ageing and Cancer Research & Treatment
  21. Advanced immunology in aging population: unveiling the complexities of vaccine responsiveness
    Yan Han, Yanhao Huang, Yuanyu Zhou, Wanke He, Gaomei Luo, Liu Yang, Yanbin Chen, Yiqi Zhu, Wei Jiang, Chanchan Xiao et al. · 2025 · Frontiers in Aging
  22. Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence
    Silvère D. Zaongo, Qiyu Yang, Mei Han, Tianlan Xi, Zilang Luo, Xin Wang, Jiadan Yang, Jing Ouyang · 2026 · Frontiers in Immunology
  23. Signal Transduction Changes in T Cells with Aging
    Tamàs Fülöp, Aurélie Y. Le Page, Gilles Dupuis, Carl F Fortin, Jacek Maciej Witkowski, Anis Larbi · 2019 · Springer eBooks
  24. A silver bullet for ageing medicine?: clinical relevance of T-cell checkpoint receptors in normal human ageing
    Leanne Rimmer, Derek A. Mann, Avan Aihie Sayer, Shoba Amarnath, Antoneta Granic · 2024 · Frontiers in Immunology
  25. Immunotherapy: should we worry about immunosenescence?
    A. Özkan, Nienke Aafke de Glas, Johanneke E. A. Portielje · 2024 · Ageing and Cancer Research & Treatment
  26. T Cell Aging: An Important Target for Perioperative Immunomodulation
    Haoning Lan, Shuyun Xu, Huili Li, Ruijuan Guo, Zhong Feng, Yun Wang · 2025 · Clinical Interventions in Aging
  27. Vitiligo as a potential degenerative disease: from oxidative stress to cellular senescence
    Yaojun Wang, Jiaoni Chi, Tao Wang, Yue Zhang, Zhimin Li, Jie Chen, Haixia Liu, Qiang Li · 2022 · Aging Pathobiology and Therapeutics
  28. Human Cytomegalovirus as a driving force towards Immunosenescence
    Zdeněk Zadražil · 2018
  29. Effects of Ageing on Adaptive Immune Responses
    Siân M. Henson · 2016 · Springer eBooks
  30. Immunological Methods and the Concept of Inflammaging in the Study of Human Aging
    Tamàs Fülöp, Graham Pawelec, Jacek Maciej Witkowski, Alan Arthur Cohen, Carl F Fortin, Aurélie Y. Le Page, Hugo Garneau, Gilles Dupuis, Anis Larbi · 2018 · Elsevier eBooks
  31. Immune checkpoint pathways in the ageing immune system and their relation to vasculitides
    Rebeca Hid Cadena · 2020
  32. AGING WITH T CELLS
    Pieren, Daniël Kees Johan · 2021
  33. Estudio celular de la inmunosenescencia en adultos mayores vacunados y en pacientes con cáncer de mama
    Rodríguez Rodríguez, Ivon Johanna · 2021
  34. Signal Transduction Changes in T-Cells with Aging
    Tamàs Fülöp, Aurélie Y. Le Page, Gilles Dupuis, Carl F Fortin, Jacek Maciej Witkowski, Anis Larbi · 2018 · Springer eBooks
  35. Clinical outcomes and safety of PD-1 inhibitors therapy in elderly patients with advanced gastric cancer
    Juanjuan Zhou, Yunlong Cai, Zhen Chen, Xiaomei Zhang, Xiaojun Xiang · 2022 · Research Square
  36. Clinical efficacy and safety analysis of receiving PD-1 inhibitor-containing regimen in elderly patients with advanced gastric cancer
    Juanjuan Zhou, Yunlong Cai, Zhen Chen, Xiaomei Zhang, Xiaojun Xiang · 2023 · Research Square
  37. [Current Status and Prospect of PD-1/PD-L1 Immune Checkpoint Inhibitor Therapy in Elderly Patients with Advanced NSCLC].
    Yunye Mao, Shu Sheng, An Wang, Jinzhao Zhai, Xiangwei Ge, Di Lu, Jinliang Wang · 2024 · PubMed Central
  38. Characterizing immune profiles in hepatocellular carcinoma patients benefiting from pembrolizumab and lenvatinib using machine learning
    Pei-Chang Lee, Po-Yu Li, Cheng-Yun Lee, Shian-Ren Lin, Chijung Wu, Y. Hung, Yu-Hua Chen, Jun-Wen Chan, Hsien-Chen Mon, Chieh-Ju Lee et al. · 2025 · BMC Cancer
  39. Additional file 6 of The effect of metformin on senescence of T lymphocytes
    Yang, Jia, Liu, Hai-Cheng, Zhang, Jian-Qing, Zou, Jian-Yong, Zhang, Xin, Chen, Wo-Ming, Gu, Yong, Hong, Hai · 2024 · Figshare
  40. Additional file 2 of The effect of metformin on senescence of T lymphocytes
    Yang, Jia, Liu, Hai-Cheng, Zhang, Jian-Qing, Zou, Jian-Yong, Zhang, Xin, Chen, Wo-Ming, Gu, Yong, Hong, Hai · 2024 · Figshare
  41. Additional file 3 of The effect of metformin on senescence of T lymphocytes
    Yang, Jia, Liu, Hai-Cheng, Zhang, Jian-Qing, Zou, Jian-Yong, Zhang, Xin, Chen, Wo-Ming, Gu, Yong, Hong, Hai · 2024 · Figshare
  42. Additional file 1 of The effect of metformin on senescence of T lymphocytes
    Yang, Jia, Liu, Hai-Cheng, Zhang, Jian-Qing, Zou, Jian-Yong, Zhang, Xin, Chen, Wo-Ming, Gu, Yong, Hong, Hai · 2023 · Figshare
  43. Additional file 5 of The effect of metformin on senescence of T lymphocytes
    Yang, Jia, Liu, Hai-Cheng, Zhang, Jian-Qing, Zou, Jian-Yong, Zhang, Xin, Chen, Wo-Ming, Gu, Yong, Hong, Hai · 2024 · Figshare
  44. Additional file 4 of The effect of metformin on senescence of T lymphocytes
    Yang, Jia, Liu, Hai-Cheng, Zhang, Jian-Qing, Zou, Jian-Yong, Zhang, Xin, Chen, Wo-Ming, Gu, Yong, Hong, Hai · 2024 · Figshare
  45. CD28 : nouvelles données sur un récepteur majeur de la costimulation lymphocytaire T
    Stéphanie O. Morin · 2017 · theses.fr (ABES)
  46. Populations lymphocytaires circulantes exprimant PD-1 au cours des cancers bronchiques avancés, valeur prédictive de réponse aux inhibiteurs de PD-1/PD-L1
    Boris Duchemann · 2021 · theses.fr (ABES)
  47. CD8+ TEMRAs in Asthma
    Richard Ramonell, Anuradha Ray · 2025 · ImmPort