AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity
Open accessAbstract
Recognition of DNA by the cell is an important immunological signature that marks the initiation of an innate immune response. AIM2 is a cytoplasmic sensor that recognizes dsDNA of microbial or host origin. Upon binding to DNA, AIM2 assembles a multiprotein complex called the inflammasome, which drives pyroptosis and proteolytic cleavage of the proinflammatory cytokines pro‐IL‐1β and pro‐IL‐18. Release of microbial DNA into the cytoplasm during infection by Francisella , Listeria , Mycobacterium , mouse cytomegalovirus, vaccinia virus, Aspergillus , and Plasmodium species leads to activation of the AIM2 inflammasome. In contrast, inappropriate recognition of cytoplasmic self‐DNA by AIM2 contributes to the development of psoriasis, dermatitis, arthritis, and other autoimmune and inflammatory diseases. Inflammasome‐independent functions of AIM2 have also been described, including the regulation of the intestinal stem cell proliferation and the gut microbiota ecology in the control of colorectal cancer. In this review we provide an overview of the latest research on AIM2 inflammasome and its role in infection, cancer, and autoimmunity.
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A cluster containing human AIM2 was identified.
“Our analysis identified a cluster containing the human protein AIM2 (O14862), which recognizes pathogenic double-stranded DNA27 and leads to the formation of the AIM2 inflammasome.”
From Clustering predicted structures at the scale of the known protein universe (2023) · cites this paper as [27]
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References 125 · Cited by 354
- Authors
- Man, S. M., Karki, R., & Kanneganti, T.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Kanneganti, Thirumala‐Devi
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2015-12-28
- Volume
- 46
- Issue
- 2
- Pages
- 269-280
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- PMC
- PMC4758349
- OpenAlex
- W2185402392
- Cited by
- 354
- References
- 125
- Citations by year
- 2026: 24 · 2025: 31 · 2024: 34 · 2023: 31 · 2022: 26 · 2021: 40 · 2020: 41 · 2019: 35 · 2018: 32 · 2017: 43 · 2016: 16
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- American Lebanese Syrian Associated Charities (CA163507, AR056296, AI101935)
- National Institutes of Health (AI 101935, CA163507)
- Medical Research Council
- National Health and Medical Research Council
- National Cancer Institute (R01CA163507, CA163507)
- National Institute of Allergy and Infectious Diseases (AI101935, R01AI101935, R37AI101935)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056296, AR-056296)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- AIM2 inflammasome, cytosolic DNA sensing, double-stranded DNA, pyroptosis, IL-1β processing, innate immunity, autoimmunity, infection, cancer, colorectal cancer, intestinal stem cells, gut microbiota, Francisella, Listeria, Mycobacterium, murine cytomegalovirus, vaccinia virus, Aspergillus, Plasmodium, psoriasis, skin inflammation, arthritis
- MeSH terms
- Animals, DNA, DNA-Binding Proteins, Humans, Immunity, Innate, Infections, Inflammation, Neoplasms, Autoimmunity, Receptors, Pattern Recognition, Mice, Inflammasomes
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