CD69: from activation marker to metabolic gatekeeper

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

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Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

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The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

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CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

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The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

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Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

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Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

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Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

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Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

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The outs and the ins of sphingosine-1-phosphate in immunity

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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

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Human T cell development, localization, and function throughout life

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C-type lectins in immunity and homeostasis

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Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

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Host-Directed Antiviral Therapy

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Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy

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Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

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Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial

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Metabolic Pathways That Control Skin Homeostasis and Inflammation

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Tissue‐resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

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Tissue-Resident Memory T Cells in Cancer Immunosurveillance

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Distinct molecular profiles of skull bone marrow in health and neurological disorders

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The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location

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Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis

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ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases

Li, D.-Y., & Xiong, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02104 · Cited by 157

CD19-specific CAR T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor are Effective in Patients with PD-L1–positive B-Cell Lymphoma

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Transcriptomic and clonal characterization of T cells in the human central nervous system

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Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia

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Human NK cells: From development to effector functions

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A unified atlas of CD8 T cell dysfunctional states in cancer and infection

Pritykin, Y., van der Veeken, J., Pine, A. R., Zhong, Y., Şahin, M., Mažutis, L., Pe’er, D., Rudensky, A. Y., & Leslie, C. S. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.045 · Cited by 117

Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis

Beltrán, E., Gerdes, L. A., Hansen, J., Flierl‐Hecht, A., Krebs, S., Blum, H., Ertl-Wagner, B. B., Barkhof, F., Kümpfel, T., Hohlfeld, R., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128475 · Cited by 130

Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung

Ogongo, P., Tezera, L. B., Ardain, A., Nhamoyebonde, S., Ramsuran, D., Singh, A., Ngoepe, A., Karim, F., Naidoo, T., Khan, K., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142014 · Cited by 120

Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy

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CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production

Yu, L., Yang, F., Zhang, F., Guo, D., Li, L., Wang, X., Liang, T., Wang, J., Cai, Z., & Jin, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0927-9 · Cited by 117

Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis

Pompura, S. L., Wagner, A., Kitz, A., Laperche, J. M., Yosef, N., Dominguez‐Villar, M., & Hafler, D. A. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138519 · Cited by 121

The T-cell Response to Epstein-Barr Virus–New Tricks From an Old Dog

Long, H. M., Meckiff, B. J., & Taylor, G. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02193 · Cited by 110

DNA Origami Nanostructures Elicit Dose‐Dependent Immunogenicity and Are Nontoxic up to High Doses In Vivo

Lucas, C. R., Halley, P. D., Chowdury, A. A., Harrington, B. K., Beaver, L. P., Lapalombella, R., Johnson, A. J., Hertlein, E. K., Phelps, M. A., Byrd, J. C., et al. (2022) · Small · doi:10.1002/smll.202108063 · Cited by 108

Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy

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The immune cell atlas of human neuroblastoma

Verhoeven, B. M., Mei, S., Olsen, T. K., Gustafsson, K. U., Valind, A., Lindström, A., Gisselsson, D., Fard, S. S., Hagerling, C., Kharchenko, P. V., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100657 · Cited by 100

Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells

Depuydt, M. A. C., Schaftenaar, F. H., Prange, K. H. M., Boltjes, A., Hemme, E., Delfos, L., de Mol, J., de Jong, M. J. M., Kleijn, M. N. A. B., Peeters, J. A. H. M., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00208-4 · Cited by 105

Regulatory T cells engineered with TCR signaling–responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter

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Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes

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Modulation of immunity by tryptophan microbial metabolites

Li, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1209613 · Cited by 104

Control of Immunoregulatory Molecules by miRNAs in T Cell Activation

Rodríguez‐Galán, A., Fernández‐Messina, L., & Sánchez‐Madrid, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02148 · Cited by 88

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

McEvoy, C. M., Murphy, J. M., Zhang, L., Clotet‐Freixas, S., Mathews, J. A., An, J., Karimzadeh, M., Pouyabahar, D., Su, S., Zaslaver, O., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35297-z · Cited by 93

The pivotal role of CD69 in autoimmunity

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Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?

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Tissue-Resident Lymphocytes in the Kidney

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Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma

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Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

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Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients

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Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells

Goldberg, M. F., Roeske, E., Ward, L. N., Pengo, T., Dileepan, T., Kotov, D. I., & Jenkins, M. K. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.009 · Cited by 81

Lung Tissue Resident Memory T-Cells in the Immune Response to Mycobacterium tuberculosis

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Co-Expression of IL-7 Improves NKG2D-Based CAR T Cell Therapy on Prostate Cancer by Enhancing the Expansion and Inhibiting the Apoptosis and Exhaustion

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Monocyte-derived S1P in the lymph node regulates immune responses

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Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation

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Immune-infiltrated kidney organoid-on-chip model for assessing T cell bispecific antibodies

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Induction of Regulatory T Cells and Correction of Cytokine Disbalance by Short-Chain Fatty Acids: Implications for Psoriasis Therapy

Schwarz, A., Philippsen, R., & Schwarz, T. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.04.031 · Cited by 87

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

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Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy

Metzloff, A. E., Padilla, M. S., Gong, N., Billingsley, M. M., Han, X., Merolle, M. I., Mai, D., Figueroa‐Espada, C. G., Thatte, A. S., Haley, R. M., et al. (2024) · Advanced Materials · doi:10.1002/adma.202313226 · Cited by 82

Recent advances in understanding inflammatory acne: Deciphering the relationship betweenCutibacterium acnesand Th17 inflammatory pathway

Mias, C., Mengeaud, V., Bessou‐Touya, S., & Duplan, H. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18794 · Cited by 88

Dietary Fiber and Microbiota Metabolite Receptors Enhance Cognition and Alleviate Disease in the 5xFAD Mouse Model of Alzheimer’s Disease

Zhou, Y., Xie, L., Schröder, J., Schuster, I. S., Nakai, M. E., Sun, G., Sun, Y., Mariño, E., Degli‐Esposti, M. A., Marques, F. Z., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0724-23.2023 · Cited by 80

The Role of Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity

Hasan, M. N., Capuk, O., Patel, S. M., & Sun, D. (2022) · Cancers · doi:10.3390/cancers14143331 · Cited by 75

Disturbed Follicular Microenvironment in Polycystic Ovary Syndrome: Relationship to Oocyte Quality and Infertility

Dai, M., Hong, L., Yin, T., & Liu, S. (2024) · Endocrinology · doi:10.1210/endocr/bqae023 · Cited by 72

Acute Myeloid Leukemia Stem Cells: The Challenges of Phenotypic Heterogeneity

Arnone, M., Konantz, M., Hanns, P., Stanger, A. M. P., Bertels, S., Godavarthy, P. S., Christopeit, M., & Lengerke, C. (2020) · Cancers · doi:10.3390/cancers12123742 · Cited by 70

Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

Knitz, M. W., Bickett, T. E., Darragh, L. B., Oweida, A. J., Bhatia, S., Court, B. V., Bhuvane, S., Piper, M., Gadwa, J., Mueller, A. C., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001955 · Cited by 71

Green synthesis of gold nanoparticles for immune response regulation: Mechanisms, applications, and perspectives

Cai, F., Li, S., Huang, H. S., Iqbal, J., Wang, C., & Jiang, X. (2021) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37281 · Cited by 73

An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression

Wang, L., Li, G., Cao, L., Dong, Y., Wang, Y., Wang, S., Li, Y., Guo, X., Zhang, Y., Sun, F., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj4796 · Cited by 69

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8+ T cells

Pangrazzi, L., Reidla, J., Arana, J. A. C., Naismith, E., Miggitsch, C., Meryk, A., Keller, M., Krause, A. A. N., Melzer, F. L., Trieb, K., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201948362 · Cited by 65

Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice

Luo, J., Zhang, Z., Sun, H., Song, J. H., Chen, X., Huang, J., Lin, X., & Zhou, R. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117191 · Cited by 68

Human mucosal tissue-resident memory T cells in health and disease

Lange, J., Rivera‐Ballesteros, O., & Buggert, M. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00467-7 · Cited by 72

Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia

Sachs, K., Sarver, A. L., Noble-Orcutt, K. E., LaRue, R. S., Antony, M. L., Chang, D., Lee, Y., Navis, C. M., Hillesheim, A. L., Nykaza, I. R., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2932 · Cited by 69

A Probody T Cell–Engaging Bispecific Antibody Targeting EGFR and CD3 Inhibits Colon Cancer Growth with Limited Toxicity

Boustany, L. M., LaPorte, S. L., Wong, L., White, C. W., Vinod, V., Shen, J., Yu, W., Koditek, D., Winter, M. B., Moore, S. J., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-2483 · Cited by 67

Targeting tissue-resident memory CD8+ T cells in the kidney is a potential therapeutic strategy to ameliorate podocyte injury and glomerulosclerosis

Li, L., Tang, W., Zhang, Y., Jia, M., Wang, L., Li, Q., Han, Q., Peng, X., Xie, Y., Wu, J., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.04.024 · Cited by 65

CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma

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Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation

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Revisiting the Coreceptor Function of Complement Receptor Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the Activation, Proliferation, and Antibody Production of Human B Cells

Kovacs, K. G., Mácsik‐Valent, B., Matkó, J., Bajtay, Z., & Erdei, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.620427 · Cited by 59

Intrahepatic CD69 + Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression

Bruni, E., Cimino, M., Donadon, M., Carriero, R., Terzoli, S., Piazza, R., Ravens, S., Prinz, I., Cazzetta, V., Marzano, P., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004579 · Cited by 59

Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

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Inactivated probiotic Bacillus coagulans GBI-30 induces complex immune activating, anti-inflammatory, and regenerative markers in vitro

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