CD69 + memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue‐resident memory T lymphocytes
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It is a matter of current debate whether the bone marrow is a hub for circulating memory T lymphocytes and/or the home of resident memory T lymphocytes. Here we demonstrate for CD69 + murine CD8 + , and CD69 + murine and human CD4 + memory T lymphocytes of the bone marrow, making up between 30 and 60% of bone marrow memory T lymphocytes, that they express the gene expression signature of tissue‐resident memory T lymphocytes. This suggests that a substantial proportion of bone marrow memory T lymphocytes are resident. It adds to previous evidence that bone marrow memory T cells are resting in terms of mobility and proliferation, and maintain exclusive long‐term memory to distinct, systemic antigens.
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Trm have been defined as independent populations by tissue retention in parabiosis experiments, by distinguishing transcriptional profiles, by exclusive Ag receptor repertoires and specificities, and by exclusive persistence in transplanted tissues.
“They have been defined as independent populations by tissue retention in parabiosis experiments [239, 240], by distinguishing transcriptional profiles [230, 241-245], by exclusive Ag receptor repertoires and specificities [243, 244, 246], and by exclusive persistence in transplanted tissues [247, 248].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [245]
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References 10 · Cited by 50
- Authors
- Siracusa, F., Durek, P., McGrath, M. A., Sercan‐Alp, Ö., Rao, A., Du, W., Cendón, C., Chang, H., Heinz, G. A., Mashreghi, M., Radbruch, A., & Dong, J.
- Affiliations
- German Rheumatism Research Centre (DE)
- Cell Biology Deutsches Rheuma‐Forschungszentrum Berlin (DRFZ), a Leibniz Institute Berlin Germany
- Corresponding author
- Dong, Jun
- ORCID
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2019-01-30
- Volume
- 49
- Issue
- 6
- Pages
- 966-968
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- PMC
- PMC6563480
- OpenAlex
- W2912132067
- Cited by
- 50
- References
- 10
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 13 · 2020: 4 · 2019: 3
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Journal of Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- European Regional Development Fund (ERDF 2014‐2020, EFRE 1.8/11, Deutsches Rheuma‐Forschungszentrum)
- Leibniz-Gemeinschaft (Leibniz Graduate School for Rheumatology (LGRh), the Leibniz Science Campus Chronic Inflammation)
- China Scholarship Council
- European Research Council (268987)
- Deutsche Forschungsgemeinschaft (Priority program 1468 IMMUNOBONE, 389687267)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- tissue-resident memory T cells, CD69, CD8+ T cells, CD4+ T cells, gene expression signatures, spleen, T cell homeostasis
- MeSH terms
- CD69 Antigens, Animals, Antigens, Differentiation, T-Lymphocyte, Bone Marrow Cells, Humans, Immunologic Memory, Spleen, Antigens, CD, T-Lymphocyte Subsets, Lectins, C-Type, Mice, Transcriptome
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