Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas–intestinal barrier axis
Open accessAbstract
The pancreas contains exocrine glands, which release enzymes (e.g., amylase, trypsin, and lipase) that are important for digestion and islets, which produce hormones. Digestive enzymes and hormones are secreted from the pancreas into the duodenum and bloodstream, respectively. Growing evidence suggests that the roles of the pancreas extend to not only the secretion of digestive enzymes and hormones but also to the regulation of intestinal homeostasis and inflammation (e.g., mucosal defense to pathogens and pathobionts). Organ crosstalk between the pancreas and intestine is linked to a range of physiological, immunological, and pathological activities, such as the regulation of the gut microbiota by the pancreatic proteins and lipids, the retroaction of the gut microbiota on the pancreas, the relationship between inflammatory bowel disease, and pancreatic diseases. We herein discuss the current understanding of the pancreas–intestinal barrier axis and the control of commensal bacteria in intestinal inflammation.
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Intestinal microbiota serves a crucial function in maintaining intestinal barrier integrity.
“Intestinal microbiota serves a crucial function in maintaining intestinal barrier integrity (Zhang et al. 2022).”
From Odoribacter laneus protects intestinal barrier by bile acid-FXR axis in acute pancreatitis (2026) · cites this paper as Zhang et al. 2022
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References 133 · Cited by 69
Research works printed but not linked: 3
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- Authors
- Zhang, Z., Tanaka, I., Pan, Z., Ernst, P. B., Kiyono, H., & Kurashima, Y.
- Affiliations
- Chiba University (JP)
- University of California San Diego (US)
- Corresponding author
- Kurashima, Yosuke
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2022-05-15
- Volume
- 52
- Issue
- 7
- Pages
- 1035-1046
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- PMC
- PMC9540119
- OpenAlex
- W4224983885
- Cited by
- 69
- References
- 133
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 19 · 2023: 9 · 2022: 1
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Journal of Immunology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- Funders
- Japan Society for the Promotion of Science (21K19494, 18KK0432)
- National Institute of Allergy and Infectious Diseases (R56AI079145, R01AI079145)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, intestinal homeostasis, intestinal inflammation, intestinal barrier, pancreatic exocrine secretion, pancreatic hormones, commensal bacteria, inflammatory bowel disease, pancreatic diseases, mucosal protection
- MeSH terms
- Gastrointestinal Microbiome, Homeostasis, Hormones, Humans, Inflammation, Intestinal Mucosa, Intestines, Pancreas
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