The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
1,2,3‐Triazole in Heterocyclic Compounds, Endowed with Biological Activity, through 1,3‐Dipolar Cycloadditions
Abstract
1,3‐Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of heterocyclic rings, with applications in different fields. In this review we focus on the synthesis of biologically active compounds possessing the 1,2,3‐triazole core through 1,3‐dipolar cycloaddition reactions. The 1,2,3‐triazole skeleton can be present as a single disubstituted ring, as a linker between two molecules, or embedded in a polyheterocycle. The cycloaddition reactions are usually catalysed by copper or ruthenium. Domino reactions can be achieved through dipolarophile anion formation, generally followed by cyclisation. The variety of attainable heterocyclic structures gives an illustration of the importance of the 1,2,3‐triazole core in medicinal chemistry.
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Cites
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Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
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Cited by
Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications
Johansson, J. R., Beke-Somfai, T., Said Stålsmeden, A., & Kann, N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00466 · Cited by 414
Gupta, A., Jamatia, R., Patil, R. A., Ma, Y.-R., & Pal, A. K. (2018) · ACS Omega · doi:10.1021/acsomega.8b00334 · Cited by 106
Metadata
- Authors
- Lauria, A., Delisi, R., Mingoia, F., Terenzi, A., Martorana, A., Barone, G., & Almerico, A. M.
- Venue
- European Journal of Organic Chemistry
- Publisher
- Wiley
- Published
- 2014-03-31
- Volume
- 2014
- Issue
- 16
- Pages
- 3289-3306
- ISSN
- 1099-0690 (ISSN-L)
- 1434-193X
- OpenAlex
- W1702491069
- Cited by
- 352
- References
- 67
- FWCI
- 13.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lauria, A., Delisi, R., Mingoia, F., Terenzi, A., Martorana, A., Barone, G., & Almerico, A. M. (2014). 1,2,3‐Triazole in Heterocyclic Compounds, Endowed with Biological Activity, through 1,3‐Dipolar Cycloadditions. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.201301695
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