MicroRNA therapeutics in cardiovascular medicine
Open accessAbstract
Cardiovascular diseases are the most common causes of human morbidity and mortality despite significant therapeutic improvements by surgical, interventional and pharmacological approaches in the last decade. MicroRNAs (miRNAs) are important and powerful mediators in a wide range of diseases and thus emerged as interesting new drug targets. An array of animal and even human miRNA-based therapeutic studies has been performed, which validate miRNAs as being successfully targetable to treat a wide range of diseases. Here, the current knowledge about miRNAs therapeutics in cardiovascular diseases on their way to clinical use are reviewed and discussed.
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Some of these molecules are currently clinically evaluated in CVD.
“Some of these molecules are currently clinically evaluated in CVD.166”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [166]
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References 70 · Cited by 193
- Authors
- Thum, T.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Thum, Thomas
- ORCID
- Thum, Thomas
- Venue
- EMBO Molecular Medicine
- Published
- 2011-12-13
- Volume
- 4
- Issue
- 1
- Pages
- 3-14
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC3376835
- OpenAlex
- W2130550747
- Cited by
- 193
- References
- 70
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 6 · 2017: 12 · 2016: 12 · 2015: 27 · 2014: 34 · 2013: 32 · 2012: 19
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- German Ministry for Education and Research (IFB‐Tx to T. T., 01EO0802)
- German Research Foundation (TH903/10‐1 to T. T.)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- miRNA-based therapy, cardiovascular disease, clinical translation, cardiovascular drug development
- MeSH terms
- Animals, Arrhythmias, Cardiac, Cardiovascular Diseases, Drug Carriers, Humans, Oligonucleotides, Neovascularization, Physiologic, MicroRNAs, Atherosclerosis
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