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Cited by 33Phytochemicals and Antioxidant ActivitiesMedicinal Plant ResearchTraditional and Medicinal Uses of Annonaceae

Antioxidant activity of banana flesh and antiproliferative effect on breast and pancreatic cancer cells

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Kim, Dae Kyeong, Ediriweera, Meran Keshawa, Davaatseren, Munkhtugs, Hyun, Ho Bong, Cho, Somi Kim·2022·Food Science & Nutrition
DOI 10.1002/fsn3.2702PMC PMC8907754
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Abstract

Bananas, one of the most widely consumed fruits worldwide, are a rich source of valuable phytochemicals. In this study, the antioxidant and the anticancer potential of banana flesh was investigated. Of the four kinds of banana flesh extracts, the hexane extract (HE) had the highest total polyphenol content (2.54 ± 0.60 mg GAE/g) and total flavonoid content (1.69 ± 0.34 mg RE/g), followed by the chloroform fraction, total ethanol extract, and ethanol fraction. HE was found to exert a strong radical scavenging activity on 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH•) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonicacid) (ABTS•) free radicals. According to the IC 50 values in various cancer cell lines, HE was found to possess the greatest cell growth inhibitory potential in human pancreatic cancer PANC‐1 cells and human triple‐negative breast cancer MDA‐MB‐231 cells. HE induced apoptosis in PANC‐1 and MDA‐MB‐231 cells, as evidenced by the appearance of condensation of chromatin, proteolytic activation of caspase‐3 and 7, and increase in the level of the cleaved form of poly (ADP‐ribose) polymerase protein. Gas chromatography mass spectrometry (GC‐MS) analysis of HE identified several anticancer compounds including palmitic acid, linoleic acid, oleic acid, campesterol, stigmasterol, and γ‐sitosterol, supporting the anticancer potential of HE. Our investigation provides a rationale for the use of banana flesh to minimize the risk of cancer‐like diseases.

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  • Banana fruit contributes about 80% of total global banana demand, meaning its peel waste is also very large.

    “Buah pisang ini menyumbang sekitar 80% dari total kebutuhan buah pisang di tingkat global, yang berarti limbah kulitnya juga sangat besar (Kim et al., 2022).”

    From Evaluasi Masker Peel Off Ekstrak Kulit Pisang Cavendish (Musa acuminata L.) dengan Variasi Konsentrasi PVA (2026) · cites this paper as Kim et al., 2022

    The Introduction (page unavailable) describes bananas as widely consumed and reports global production of approximately 116 million tons. It does not state that the banana fruit in question accounts for 80% of global demand or quantify peel waste; the Methods only notes that peel was separated from flesh. (LLM, conf=0.82)

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Cited by

Sorted by citations

Authors
Kim, D. K., Ediriweera, M. K., Davaatseren, M., Hyun, H. B., & Cho, S. K.
Affiliations
  • Jeju National University (KR)
  • Jeju TechnoPark (KR)
Corresponding author
Cho, Somi Kim
ORCID
Venue
Food Science & Nutrition
Publisher
Wiley
Published
2022-01-26
Volume
10
Issue
3
Pages
740-750
ISSN
2048-7177 (ISSN-L)
DOI
10.1002/fsn3.2702
PMC
PMC8907754
OpenAlex
W4210256728
Cited by
33
References
5
Citations by year
2026: 7 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 4
FWCI
3.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Food Science & Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministry of Higher Education and Scientific Research
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Traditional and Medicinal Uses of Annonaceae
Keywords
antioxidant activity, antiproliferative activity, breast cancer, pancreatic cancer, hexane extract, polyphenols, flavonoids, free radical scavenging, apoptosis, caspase-3, caspase-7, PANC-1 cells, MDA-MB-231 cells, phytosterols, campesterol, stigmasterol, γ-sitosterol, fatty acids, anticancer phytochemicals

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