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Phytobioactive compounds as therapeutic agents for human diseases: A review
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Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present-day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, and inflammation. The data for this review were collected from Google Scholar, PubMed, Directory of Open Access Journals (DOAJ), and Science Direct by using keywords: "Medicinal plants, Phytobioactive compounds, Polyphenols, Alkaloids, Carotenoids etc." Several studies have reported the pharmacological and therapeutic potential of the phytobioactives. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti-inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic activities. This literature review was planned to provide comprehensive insight into the biopharmacological and therapeutic potential of phytobioactive compounds. The techniques used for the extraction and isolation of phytobioactive compounds, and bioassays required for their biological activities such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities, have been discussed. Characterization techniques for the structural elucidation of phytobioactive compounds such as HPLC, TLC, FTIR, GC-MS/MS, and NMR have also been discussed. This review concludes that phytobioactive compounds may be used as potential alternative to synthetic compounds as therapeutic agents for the treatment of various diseases.
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“Phytochemicals like alkaloids, flavonoids, and terpenoids have demonstrated potential in addressing neurodegenerative diseases (NNDs), including AD, by combating oxidative stress, minimizing inflammation, and protecting neurons [13,14].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [13]
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Metadata
- Authors
- Riaz, M., Khalid, R., Afzal, M., Anjum, F., Fatima, H., Zia, S., Rasool, G., Egbuna, C., Mtewa, A. G., Uche, C. Z., & Aslam, M. A.
- Affiliations
- University of Sargodha (PK)
- University of Agriculture Faisalabad (PK)
- Hill Fruit Research Station Sunny Bank Murree Pakistan
- Government College University, Faisalabad (PK)
- University of Central Punjab (PK)
- University of Port Harcourt (NG)
- Malawi University of Science and Technology (MW)
- University of Nigeria (NG)
- Corresponding author
- Riaz, Muhammad
- Anjum, Fozia
- ORCID
- Venue
- Food Science & Nutrition
- Publisher
- Wiley
- Published
- 2023-04-17
- Volume
- 11
- Issue
- 6
- Pages
- 2500-2529
- ISSN
- 2048-7177 (ISSN-L)
- PMC
- PMC10261751
- OpenAlex
- W4366287784
- Cited by
- 355
- References
- 220
- Citations by year
- 2026: 153 · 2025: 118 · 2024: 73 · 2023: 10
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Food Science & Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Keywords
- plant secondary metabolites, medicinal plants, polyphenols, alkaloids, terpenes, polysaccharides, antioxidant activity, anticancer activity, anti-inflammatory activity, cardioprotective activity, hepatoprotection, neuroprotective activity, antidiabetic activity, antimicrobial activity, cytotoxicity, oxidative stress, antibiotic resistance, structure elucidation, bioassay
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