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The effect of Chlorella supplementation in pregnant women with low‐grade inflammation
Open accessAbstract
Pregnancy dramatically changes maternal metabolism and the microbiome. Low‐grade inflammation can cause maternal complications and fetal abnormalities. The objective of this open‐label, randomized, controlled study was to evaluate the efficacy and safety of orally administered Chlorella, a green alga that is commercially available as a dietary supplement with rich nutrients and dietary fiber for pregnant women with low‐grade inflammation. Patients with C‐reactive protein levels >0.05 mg/dL (16 weeks gestation, n = 22) were enrolled and randomly allocated to the Chlorella group (n = 10) or control group (n = 12). We conducted blood biochemical tests at 25, 30, and 35 weeks gestation and evaluated the evacuation status (symptoms depending on the Rome IV C2 criteria and laxative usage), side effects, and complications throughout the investigation. We also monitored the status of the offspring. The Chlorella group (n = 0) showed a significantly lower rate of constipation than the control group (n = 8). This study demonstrated the beneficial effects and safety of Chlorella supplementation in pregnant women, which prevented constipation and unnecessary laxative administration.
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“Additionally, Chlorella vulgaris provides a rich source of vitamins (A, B, C, and E) and minerals such as calcium, potassium, magnesium, and zinc, all of which are essential for metabolism, tissue regeneration, and DNA biosynthesis (Uchiyama-Tanaka et al., 2024; Wang et al., 2024).”
From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Uchiyama-Tanaka et al., 2024
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Cites
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214
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Cited by
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Microalgae biotechnology and its role in sustainable and healthy food design
Schneider, A. T., Machado, R. L. S., Dutra, D. A., Machado, E. F., Dias, R. R., Deprá, M. C., Zepka, L. Q., & Jacob-Lopes, E. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1716473 · Cited by 15
“Additionally, Chlorella vulgaris provides a rich source of vitamins (A, B, C, and E) and minerals such as calcium, potassium, magnesium, and zinc, all of which are essential for metabolism, tissue regeneration, and DNA biosynthesis (Uchiyama-Tanaka et al., 2024; Wang et al., 2024).”
Metadata
- Authors
- Uchiyama‐Tanaka, Y., Shimabukuro, F., Okumura, E., & Fujishima, M.
- Affiliations
- Yoko Clinic Kitakyushu, Fukuoka Japan
- Yui Clinic Noborikawa Okinawa Japan
- Sun Chlorella Corp Kyoko Japan
- Corresponding author
- Uchiyama‐Tanaka, Yoko
- Venue
- Food Science & Nutrition
- Publisher
- Wiley
- Published
- 2023-10-16
- Volume
- 12
- Issue
- 1
- Pages
- 292-297
- ISSN
- 2048-7177 (ISSN-L)
- PMC
- PMC10804112
- OpenAlex
- W4387669898
- Cited by
- 4
- References
- 1
- Citations by year
- 2025: 4
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Food Science & Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- Chlorella, dietary supplementation, pregnancy, low-grade inflammation, C-reactive protein, constipation, laxative use, green algae, maternal nutrition, fetal outcomes, gut microbiota
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