The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
EWSR1‐CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma
Abstract
The molecular hallmark of angiomatoid fibrous histiocytoma (AFH) is not well defined, with only six cases with specific gene fusions reported to date, consisting of either FUS‐ATF1 or EWSR1‐ATF1. To address this, we investigated the presence of FUS‐ATF1, EWSR1‐ATF1, and the highly related EWSR1‐CREB1 fusion in a group of nine AFHs. All cases were subjected to RT‐PCR for EWSR1‐ATF1 and EWSR1‐CREB1. FISH for EWSR1 and FUS rearrangements was performed in most cases. Transcriptional profiling was performed in three tumors and their gene expression was compared to five clear cell sarcomas expressing either the EWSR1‐ATF1 or EWSR1‐CREB1 fusion. By RT‐PCR, eight out of nine tumors showed the presence of the EWSR1‐CREB1 fusion, while one had an EWSR1‐ATF1 transcript. FISH showed evidence of EWSR1 rearrangement in seven out of eight cases. Karyotypic analysis performed in one tumor showed a t(2;22)(q33;q12). High transcript levels were noted for TFE3 in AFH tumors, while overexpression of genes involved in melanogenesis, such as MITF, GP100, and MET was noted in somatic clear cell sarcomas. We report for the first time the presence of EWSR1‐CREB1 in AFH, which now appears to be the most frequent gene fusion in this tumor. EWSR1‐CREB1 is a novel translocation recently described in clear cell sarcoma of the GI tract. EWSR1‐ATF1, identified in some AFH cases, is the most common genetic abnormality in soft tissue clear cell sarcoma. Thus, identical fusions involving ATF1 and CREB1 are found in two distinct sarcomas, which may be able to transform two different types of mesenchymal precursor cells, unlike most other sarcoma gene fusions. © 2007 Wiley‐Liss, Inc.
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EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts
Zucman, J., Delattre, O., Desmaze, C., Epstein, A. L., Stenman, G., Speleman, F., Fletchers, C. D. M., Aurias, A., & Thomas, G. (1993) · Nature Genetics · doi:10.1038/ng0893-341 · Cited by 502
Antonescu, C. R., Tschernyavsky, S. J., Decuseara, R., Leung, D. H. Y., Woodruff, J. M., Brennan, M. F., Bridge, J. A., Neff, J. R., Goldblum, J. R., & Ladanyi, M. (2001) · PubMed · Cited by 327
Self-citationTsuda, M., Davis, I. J., Argani, P., Shukla, N., McGill, G. G., Nagai, M., Saito, T., Laé, M., Fisher, D. E., & Ladanyi, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2855 · Cited by 306
Self-citationOncogenic MITF dysregulation in clear cell sarcoma: Defining the MiT family of human cancers
Davis, I. J., Kim, J. J., Ozsolak, F., Widlund, H. R., Rozenblatt-Rosen, O., Granter, S. R., Du, J., Fletcher, J. A., Denny, C. T., Lessnick, S. L., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.021 · Cited by 202
Molecular Diagnosis of Clear Cell Sarcoma
Antonescu, C. R., Tschernyavsky, S. J., Woodruff, J. M., Jungbluth, A. A., Brennan, M. F., & Ladanyi, M. (2002) · The Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60679-4 · Cited by 198
Self-citationClassification of Clear-Cell Sarcoma as a Subtype of Melanoma by Genomic Profiling
Segal, N. H., Pavlidis, P., Noble, W. S., Antonescu, C. R., Viale, A., Wesley, U. V., Busam, K., Gallardo, H., DeSantis, D., Brennan, M. F., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.10.108 · Cited by 197
Self-citationc-Met Expression Is Regulated by Mitf in the Melanocyte Lineage
McGill, G. G., Haq, R., Nishimura, E. K., & Fisher, D. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513094200 · Cited by 174
Nord, K. H., Mertens, F., Jin, Y., Meis‐Kindblom, J. M., Kindblom, L., Behrendtz, M., Kalén, A., Mandahl, N., & Panagopoulos, I. (2005) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20201 · Cited by 155
CREB: the unindicted cancer co-conspirator
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Cited by
The evolving classification of soft tissue tumours: an update based on the new WHO classification
Fletcher, C. D. M. (2006) · Histopathology · doi:10.1111/j.1365-2559.2005.02284.x · Cited by 913
Self-citationFletcher, C. D. M. (2014) · Histopathology · doi:10.1111/his.12267 · Cited by 441
Self-citationSarcoma care in the era of precision medicine
Wallander, K., Öfverholm, I., Boye, K., Tsagkozis, P., Papakonstantinou, A., Lin, Y., & Haglund de Flon, F. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13717 · Cited by 30
Metadata
- Authors
- Antonescu, C. R., Dal Cin, P., Nafa, K., Teot, L. A., Surti, U., Fletcher, C. D., & Ladanyi, M.
- Venue
- Genes, Chromosomes and Cancer
- Publisher
- Wiley
- Published
- 2007-08-20
- Volume
- 46
- Issue
- 12
- Pages
- 1051-1060
- ISSN
- 1045-2257 (ISSN-L)
- 1098-2264
- OpenAlex
- W2092289690
- Cited by
- 309
- References
- 11
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- closed
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