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Cytogenetics of papillary renal cell tumors
Abstract
Chromosome aberrations were determined in short‐term cultures of 18 papillary renal cell tumors, as well as in the cell line ACHN, and the results were evaluated together with 20 previously published cases. We found that chromosomes 7, 17, and 16 and the Y chromosome were specifically involved in the karyotype changes in this tumor type. A combination of tri‐ or tetrasomy 7 and trisomy 17, as the only autosomal karyotype changes, marks benign papillary renal cell adenomas (ten cases). Malignant papillary renal cell carcinomas (29 cases) were characterized by additional trisomies: trisomy 16 occurred in 20 tumors, and trisomy 12 and 20 in 8 tumors each. Loss of the Y chromosome was observed in 7 of 9 benign and in 23 of 25 malignant tumors that developed in males. None of the papillary renal cell adenomas or carcinomas showed a loss of 3p or gain of a 5q segment, both of which are characteristic of common non‐papillary renal cell carcinomas.
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Citations
Cited by
Mutations of the VHL tumour suppressor gene in renal carcinoma
Gnarra, J. R., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, H., Latif, F., Liu, S., Chen, F., Duh, F.-M., et al. (1994) · Nature Genetics · doi:10.1038/ng0594-85 · Cited by 1,730
du Manoir, S., Speicher, M. R., Joos, S., Schröck, E., Popp, S., Döhner, H., Kovacs, G., Robert-Nicoud, M., Lichter, P., & Cremer, T. (1993) · Human Genetics · doi:10.1007/bf00202476 · Cited by 555
Self-citationHereditary Papillary Renal Cell Carcinoma
Zbar, B., Tory, K., Merino, M., Schmidt, L., Glenn, G., Choyke, P., Walther, M. M., Lerman, M., & Linehan, W. M. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)35015-2 · Cited by 308
Quantitative analysis of comparative genomic hybridization
du Manoir, S., Schröck, E., Bentz, M., Speicher, M. R., Joos, S., Ried, T., Lichter, P., & Cremer, T. (1995) · Cytometry · doi:10.1002/cyto.990190105 · Cited by 293
Choosing the right cell line for renal cell cancer research
Brodaczewska, K. K., Szczylik, C., Fiedorowicz, M., Porta, C., & Czarnecka, A. M. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0565-8 · Cited by 267
Metadata
- Authors
- Kovacs, G., Fuzesi, L., Emanuel, A., & Kung, H.
- Venue
- Genes, Chromosomes and Cancer
- Publisher
- Wiley
- Published
- 1991-07
- Volume
- 3
- Issue
- 4
- Pages
- 249-255
- ISSN
- 1045-2257 (ISSN-L)
- 1098-2264
- OpenAlex
- W2150954721
- Cited by
- 320
- References
- 0
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kovacs, G., Fuzesi, L., Emanuel, A., & Kung, H. (1991). Cytogenetics of papillary renal cell tumors. Genes, Chromosomes and Cancer. https://doi.org/10.1002/gcc.2870030403
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