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t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia
Abstract
A t(12;21)(p11 ‐p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p‐ abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10 +, CD19 + ). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21‐q22 were performed to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.2 in one patient. Although only one case of ALL with t( 12;21) has been reported previously, the present results suggest that t( 12;21) is a recurrent translocation in ALL. Genes Chrom Cancer 9:186‐191 (1994). © 1994 Wiley‐Liss, Inc.
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Citations
Cited by
Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.
Golub, T. R., Barker, G. F., Bohlander, S. K., Hiebert, S. W., Ward, D. C., Bray-Ward, P., Morgan, E., Raimondi, S. C., Rowley, J. D., & Gilliland, D. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4917 · Cited by 704
The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion
Romana, S., Mauchauffe, M., Le Coniat, M., Chumakov, I., Le Paslier, D., Berger, R., & Bernard, O. (1995) · Blood · doi:10.1182/blood.v85.12.3662.bloodjournal85123662 · Cited by 530
Self-citationHigh frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia
Romana, S., Poirel, H., Leconiat, M., Flexor, M., Mauchauffe, M., Jonveaux, P., Macintyre, E., Berger, R., & Bernard, O. (1995) · Blood · doi:10.1182/blood.v86.11.4263.bloodjournal86114263 · Cited by 427
Self-citationClinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia
Faderl, S., Kantarjian, H. M., Talpaz, M., & Estrov, Z. (1998) · Blood · doi:10.1182/blood.v91.11.3995 · Cited by 335
Metadata
- Authors
- Romana, S. P., Coniat, M. L., & Berger, R.
- Venue
- Genes, Chromosomes and Cancer
- Publisher
- Wiley
- Published
- 1994-03
- Volume
- 9
- Issue
- 3
- Pages
- 186-191
- ISSN
- 1045-2257 (ISSN-L)
- 1098-2264
- OpenAlex
- W2022340851
- Cited by
- 219
- References
- 0
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Romana, S. P., Coniat, M. L., & Berger, R. (1994). t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia. Genes, Chromosomes and Cancer. https://doi.org/10.1002/gcc.2870090307
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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