The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Truncated product method for combining P‐values
Abstract
We present a new procedure for combining P‐values from a set of L hypothesis tests. Our procedure is to take the product of only those P‐values less than some specified cut‐off value and to evaluate the probability of such a product, or a smaller value, under the overall hypothesis that all L hypotheses are true. We give an explicit formulation for this P‐value, and find by simulation that it can provide high power for detecting departures from the overall hypothesis. We extend the procedure to situations when tests are not independent. We present both real and simulated examples where the method is especially useful. These include exploratory analyses when L is large, such as genome‐wide scans for marker‐trait associations and meta‐analytic applications that combine information from published studies, with potential for dealing with the “publication bias” phenomenon. Once the overall hypothesis is rejected, an adjustment procedure with strong family‐wise error protection is available for smaller subsets of hypotheses, down to the individual tests. Genet. Epidemiol. 22:170–185, 2002. © 2002 Wiley‐Liss, Inc.
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
An improved Bonferroni procedure for multiple tests of significance
SIMES, R. J. (1986) · Biometrika · doi:10.1093/biomet/73.3.751 · Cited by 2,396
Multiple Comparison Procedures
Hochberg, Y., & Tamhane, A. C. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316672 · Cited by 2,389
Cited by
Arguments for rejecting the sequential Bonferroni in ecological studies
Moran, M. D. (2003) · Oikos · doi:10.1034/j.1600-0706.2003.12010.x · Cited by 1,484
A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic
Madsen, B. E., & Browning, S. R. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000384 · Cited by 1,113
Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P -values
Pedersen, B. S., Schwartz, D. A., Yang, I. V., & Kechris, K. J. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts545 · Cited by 485
Evaluating the evaluation of cancer driver genes
Tokheim, C. J., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., & Karchin, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616440113 · Cited by 384
Moskvina, V, Craddock, N., Holmans, P., Nikolov, I., Pahwa, J. S., Green, E., Wellcome Trust Case Control Consortium, Owen, M. J., & O'Donovan, M. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.133 · Cited by 363
Metadata
- Authors
- Zaykin, D. V., Zhivotovsky, L. A., Westfall, P. H., & Weir, B. S.
- Venue
- Genetic Epidemiology
- Publisher
- Wiley
- Published
- 2002-01-10
- Volume
- 22
- Issue
- 2
- Pages
- 170-185
- ISSN
- 0741-0395 (ISSN-L)
- 1098-2272
- OpenAlex
- W2073116379
- Cited by
- 513
- References
- 3
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- closed
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