Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair

Marriott, Mark P.; Emery, Ben; Cate, Holly S.; Binder, Michele D.; Kemper, Dennis; Wu, Qizhu; Kolbe, Scott; Gordon, Ian R.; Wang, Hong; Egan, Gary; Murray, Simon; Butzkueven, Helmut; Kilpatrick, Trevor J.

doi:10.1002/glia.20646

Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair

Leukemia inhibitory factor (LIF) receptor signaling limits the severity of inflammatory demyelination in experimental autoimmune encephalomyelitis, a T-cell dependent animal model of multiple sclerosis (MS) [Butzkueven et al. (2002) Nat Med 8:613-619]. To identify whether LIF exerts direct effect…