Cited by 266Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research
Triple‐transgenic Alzheimer's disease mice exhibit region‐specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology
Open accessDesai, Maya K., Sudol, Kelly L., Janelsins, Michelle C., Mastrangelo, Michael A., Frazer, Maria E., Bowers, William J.·2009·Glia
DOI 10.1002/glia.20734PMC PMC2584762
Abstract
Alzheimer's disease (AD) is a progressively debilitating brain disorder pathologically defined by extracellular amyloid plaques, intraneuronal neurofibrillary tangles, and synaptic disintegrity. AD has not been widely considered a disease of white matter, but more recent evidence suggests the existence of abnormalities in myelination patterns and myelin attrition in AD-afflicted human brains. Herein, we demonstrate that triple-transgenic AD (3xTg-AD) mice, which harbor the human amyloid precursor protein Swedish mutant transgene, presenilin knock-in mutation, and tau P301L mutant transgene, exhibit significant region-specific alterations in myelination patterns and in oligodendrocyte marker expression profiles at time points preceding the appearance of amyloid and tau pathology. These immunohistochemical signatures are coincident with age-related alterations in axonal and myelin sheath ultrastructure as visualized by comparative electron microscopic examination of 3xTg-AD and nontransgenic mouse brain tissue. Overall, these findings indicate that 3xTg-AD mice represent a viable model in which to examine mechanisms underlying AD-related myelination and neural transmission defects that occur early during presymptomatic stages of the disease process.
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AD pathology in the white matter includes loss of myelin and a decrease in oligodendrocyte proteins.
“AD pathology in the white matter includes the loss of myelin and a decrease in oligodendrocyte proteins [62–68].”
From Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts (2016) · cites this paper as [66]
Abnormal myelination patterns have been identified prior to appearance of NFTs and amyloid plaques in a mouse model exhibiting both pathologies.
“Abnormal myelination patterns have been identified prior to appearance of NFTs and amyloid plaques in a mouse model exhibiting both pathologies (Desai et al., 2009).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Desai et al., 2009
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- Authors
- Desai, M. K., Sudol, K. L., Janelsins, M. C., Mastrangelo, M. A., Frazer, M. E., & Bowers, W. J.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Bowers, William J.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2008-07-25
- Volume
- 57
- Issue
- 1
- Pages
- 54-65
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- PMC
- PMC2584762
- OpenAlex
- W2007812767
- Cited by
- 266
- References
- 68
- Citations by year
- 2026: 13 · 2025: 30 · 2024: 22 · 2023: 31 · 2022: 17 · 2021: 14 · 2020: 19 · 2019: 12 · 2018: 17 · 2017: 7 · 2016: 11 · 2015: 14 · 2014: 9 · 2013: 14 · 2012: 11
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG023593, R01AG026328)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, myelination, white matter, oligodendrocytes, 3xTg-AD mice, amyloid precursor protein, presenilin, P301L tau, axons, presymptomatic disease
- MeSH terms
- Age Factors, Alzheimer Disease, Animals, Brain, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Myelin Sheath, Nerve Fibers, Myelinated, tau Proteins, Tauopathies, Mice, Plaque, Amyloid
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