APOE genotype alters glial activation and loss of synaptic markers in mice

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Items 101–200 of 228

1. Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis
   Laura Madrid, Alzheimer’s Disease Neuroimaging Initiative, Sonia Moreno–Grau, Shahzad Ahmad, Antonio González-Pérez, Itziar de Rojas, Rui Xia, Pamela V. Martino Adami, Pablo García‐González, Luca Kleineidam et al. · 2021 · Aging
2. Apolipoprotein E Polymorphism and Oxidative Stress in Peripheral Blood-Derived Macrophage-Mediated Amyloid-Beta Phagocytosis in Alzheimer’s Disease Patients
   P.S. Jairani, Aswathy Peethambaran Mallika, Dhanya Krishnan, Ramshekhar N. Menon, Joe Verghese, Pavagada Sivasankara Mathuranath, Srinivas Gopala · 2019 · Cellular and Molecular Neurobiology
3. An Overview of Astrocyte Responses in Genetically Induced Alzheimer’s Disease Mouse Models
   Fokion Spanos, Shane Antony Liddelow · 2020 · Cells
4. Alzheimer’s Disease, Astrocytes and Kynurenines
   Lívia Dézsi, Bernadett Tuka, Diána Martos, László Vécsei · 2015 · Current Alzheimer Research
5. Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling
   Charles E Seaks, Erica M. Weekman, Tiffany L. Sudduth, Kevin Xie, Brandi Wasek, David W. Fardo, Lance A. Johnson, Teodoro Bottiglieri, Donna M. Wilcock · 2022 · Journal of Cerebral Blood Flow & Metabolism
6. Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease
   Ole Isacson A, Oeystein Roed Brekk, Penelope J. Hallett · 2019 · Frontiers in Neurology
7. Identification and modification of amyloid-independent phenotypes of APOE4 mice
   Amanda Marie DiBattista, Sonya B. Dumanis, Joshua Newman, George William Rebeck · 2016 · Experimental Neurology
8. APOE Genotype Specific Effects on the Early Neurodegenerative Sequelae Following Chronic Repeated Mild Traumatic Brain Injury
   Phillip M. Muza, Corbin J. Bachmeier, Benoit Mouzon, Moustafa Algamal, Naomi G. Rafi, Carlyn Lungmus, Laila I. Abdullah, James E. Evans, Scott Ferguson, MICHAEL J. MULLAN et al. · 2019 · Neuroscience
9. The influence of ApoE4 on the clinical outcomes and pathophysiology of degenerative cervical myelopathy
   Alexa Maria Lena Desimone, James Hong, Sydney T. Brockie, Wenru Yu, Alex M. Laliberté, Michael George Fehlings · 2021 · JCI Insight
10. PET Imaging in Animal Models of Alzheimer’s Disease
    Baosheng Chen, Bernadette V. Marquez-Nostra, Erika Belitzky, Takuya Toyonaga, Jie Tong, Yiyun Henry Huang, Zhengxin Cai · 2022 · Frontiers in Neuroscience
11. How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative model
    Jaisalmer de Frutos‐Lucas, Kelsey R. Sewell, Alejandra García‐Colomo, Shaun J. Markovic, Kirk I. Erickson, Belinda M. Brown · 2023 · Alzheimer s Research & Therapy
12. Immunity and amyloid beta, total tau and neurofilament light chain: Findings from a community‐based cohort study
    Lana Fani, Shahzad Ahmad, M. Kamran Ikram, Mohsen Ghanbari, M. Arfan Ikram · 2020 · Alzheimer s & Dementia
13. High-fat diet increases gliosis and immediate early gene expression in APOE3 mice, but not APOE4 mice.
    Jones, Nahdia S., Watson, Katarina Q., Rebeck, G. William · 2021 · Journal of Neuroinflammation
14. The detrimental effects of APOE4 on risk for Alzheimer's disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha
    Lisa R. Taxier, Sarah M. Philippi, Jason M. York, Mary Jo LaDu, Karyn M. Frick · 2021 · Neurobiology of Aging
15. <scp>ApoE4</scp> expression disrupts tau uptake, trafficking, and clearance in astrocytes
    Eisenbaum, Maxwell, Pearson, Andrew, Ortiz, Camila, Mullan, Michael, Crawford, Fiona, Ojo, Joseph, Bachmeier, Corbin · 2024 · Glia
16. The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype
    Tamar C. Demby, Phillip S. Gross, Jeanne S. Mandelblatt, Jeffrey K. Huang, George William Rebeck · 2023 · Experimental Neurology
17. Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner
    Amanda Marie DiBattista, Sonya B. Dumanis, Jung Min Song, Guojun Bu, Edwin J. Weeber, George William Rebeck, Hyang-Sook Hoe · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
18. ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment
    Jing Zhang, Lanyan Lin, Xiaoman Dai, Naian Xiao, Qinyong Ye, Xiaochun Chen · 2021 · Journal of Psychiatric Research
19. APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release
    Nicole Koutsodendris, Jessica R. Blumenfeld, Ayushi Agrawal, Michela Traglia, Oscar Yip, Antara T. Rao, Min Joo Kim, Maxine R. Nelson, Yung-Hua Wang, Brian P. Grone et al. · 2023 · Cell Reports
20. Two Alzheimer’s disease risk genes increase entorhinal cortex volume in young adults
    Amanda Marie DiBattista, Benson W. Stevens, George William Rebeck, Adam E. Green · 2014 · Frontiers in Human Neuroscience
21. Uncovering mechanisms of brain inflammation in Alzheimer's disease with APOE4 : Application of single cell‐type lipidomics
    Isaac Asante, Stan G. Louie, Hussein N. Yassine · 2022 · Annals of the New York Academy of Sciences
22. The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction
    Keith W. VanDusen, Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, Kenneth Roberts, John Whittle, Jeffrey N. Browndyke et al. · 2020 · Journal of Alzheimer s Disease
23. Lipoprotein Particles in Cerebrospinal Fluid
    Maki Tsujita, John Melchior, Shinji Yokoyama · 2024 · Arteriosclerosis Thrombosis and Vascular Biology
24. Apolipoprotein E in Alzheimer’s Disease: Focus on Synaptic Function and Therapeutic Strategy
    Longjie Qu, Shuai Xu, Zhen Lan, Shuang Fang, Yun Xu, Xiaolei Zhu · 2024 · Molecular Neurobiology
25. The APOE–Microglia Axis in Alzheimer’s Disease: Functional Divergence and Therapeutic Perspectives—A Narrative Review
    Aiwei Liu, Tingyue Wang, Liu Yang, Yu Zhou · 2025 · Brain Sciences
26. Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice
    Isha Mhatre‐Winters, Aseel Eid, Yoonhee Han, Kim Tieu, Jason R. Richardson · 2023 · ASN NEURO
27. Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation
    Ana Carolina Valencia‐Olvera, Deebika Balu, Naomi Faulk, Aspasia Amiridis, Yueting Wang, Christine Pham, Eva Avila-Munoz, Jason M. York, Gregory R. J. Thatcher, Mary Jo LaDu · 2023 · Neurotherapeutics
28. A Levee to the Flood: Pre-injury Neuroinflammation and Immune Stress Influence Traumatic Brain Injury Outcome
    Samuel Houle, Olga N. Kokiko‐Cochran · 2022 · Frontiers in Aging Neuroscience
29. Apolipoprotein E‐ε4 deficiency and cognitive function in hepatitis C virus‐infected patients
    Matthew A. Wozniak, L. M. Lugo Iparraguirre, Meike Dirks, Milani Deb‐Chatterji, Henning Pflugrad, Annemarie Goldbecker, Anita B. Tryc, Hans Worthmann, Markus Gess, Mary M.E. Crossey et al. · 2015 · Journal of Viral Hepatitis
30. Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity
    Aidan L. Neustadtl, Charisse N. Winston, Maia Parsadanian, Bevan S. Main, Sonia Villapol, Mark P. Burns · 2017 · Neuroreport
31. Retinal dysfunction in APOE4 knock‐in mouse model of Alzheimer's disease
    Surabhi D. Abhyankar, Qianyi Luo, Gabriella D. Hartman, Neha S. Mahajan, Timothy W. Corson, Adrian L. Oblak, Bruce T. Lamb, Ashay Dilip Bhatwadekar · 2025 · Alzheimer s & Dementia
32. ApoE and clusterin CSF levels influence associations between APOE genotype and changes in CSF tau, but not CSF Aβ42, levels in non-demented elderly
    Rosalinde E.R. Slot, Maartje I. Kester, Argonde C. van Harten, Wesley Jongbloed, Femke H. Bouwman, Charlotte Elisabeth Teunissen, Philip Scheltens, Wiesje M. van der Flier, Robert Veerhuis · 2019 · Neurobiology of Aging
33. APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid1
    Miles Berger, Mary Cooter, Alexander Scott Roesler, Stacey Chung, John Park, Jennifer L. Modliszeski, Keith W. VanDusen, J. Will Thompson, Martin Arthur Moseley, Michael J. Devinney et al. · 2020 · Journal of Alzheimer s Disease
34. RETRACTED ARTICLE: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
    Shaowei Wang, Boyang Li, Victoria A. Solomon, Alfred Nji Fonteh, Stanley Isaac Rapoport, David Alan Bennett, Zoe Arvanitakis, Helena Chang Chui, Carol A. Miller, Patrick M. Sullivan et al. · 2021 · Molecular Neurodegeneration · Retracted
35. Hyperactive glial cells contribute to axonal pathologies in the spinal cord of Npc1 mutant mice
    Xin Yan, Fan Yang, Jan Lukáš, Martin Witt, Andreas Wree, Arndt Rolfs, Jiankai Luo · 2014 · Glia
36. APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer’s Disease and Cardiovascular Disease
    Чан Лю, Juan Liu, Yanyang Wang, Shang-Fu Xu, Li-Mei Yu · 2025 · Molecular Neurobiology
37. Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease
    Joana Saavedra, Mariana Nascimento, Márcia A. Liz, Isabel Cardoso · 2022 · Frontiers in Cell and Developmental Biology
38. Human stem cell transplantation models of Alzheimer’s disease
    Nkechime Ifediora, Peter Canoll, Gunnar Hargus · 2024 · Frontiers in Aging Neuroscience
39. Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitro
    Shivesh Ghura, Leon M. Tai, Ming Zhao, Nicole Collins, Chun‐Tao Che, Katherine M. Warpeha, Mary Jo LaDu · 2016 · Scientific Reports
40. Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOE ε3, but not APOE ε4, targeted replacement mice
    Chunsun Jiang, Luke T. Stewart, Hui‐Chien Kuo, William McGilberry, Stephanie Brook Wall, Bill Liang, Thomas van Groen, Shannon M. Bailey, Young-il Kim, Trent E. Tipple et al. · 2019 · Neurobiology of Aging
41. Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn
    Siyi Liu, Shuting Yang, Xuan Zhu, Xiang Li, Xi Zhang, Xiaoqiong Zhou, Hong Cheng, Fu-Quan Huo, Qingxiang Mao, Lingli Liang · 2023 · Biology Direct
42. Role of nerve growth factor on cognitive impairment in patients with Alzheimer's disease carrying apolipoprotein E ε4
    Mingyue He, Zhan Liu, Tenghong Lian, Peng Fei Guo, Wenjing Zhang, Yue Ming Huang, Yanan Zhang, Gaifen Liu, Weijiao Zhang, Jinghui Li et al. · 2023 · CNS Neuroscience & Therapeutics
43. AOP report: Development of an adverse outcome pathway for deposition of energy leading to learning and memory impairment
    Ahmad Sleiman, Kathleen B. Miller, Danicia Flores, Jaqueline Kuan, Kaitlyn Altwasser, Benjamin J. Smith, Tatiana Kozbenko, Robyn Hocking, Scott J. Wood, Janice L. Huff et al. · 2024 · Environmental and Molecular Mutagenesis
44. Modeling Alzheimer’s Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational Modeling
    Anna M. Timofeeva, Kseniya S. Aulova, Georgy A. Nevinsky · 2025 · Brain Sciences
45. The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases
    Sara Travaglione, Stefano Loizzo, Giulia Ballan, Carla Fiorentini, Alessia Fabbri · 2014 · Toxins
46. Correction: CNF1 Increases Brain Energy Level, Counteracts Neuroinflammatory Markers and Rescues Cognitive Deficits in a Murine Model of Alzheimer's Disease
    Stefano Loizzo, Roberto Rimondini, Sara Travaglione, Alessia Fabbri, Marco Guidotti, Alberto Ferri, Gabriele Campana, Carla Fiorentini · 2013 · PLoS ONE
47. Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin.
    David Graykowski, Kyle Kasparian, John L. Caniglia, Yelena Gritsaeva, E. Cudaback · 2020 · Journal of Neuroimmunology
48. A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease
    Haimeng Bai, Adam Christian Naj, Penelope H. Benchek, Logan C. Dumitrescu, Timothy J. Hohman, Kara L. Hamilton‐Nelson, Asha R. Kallianpur, Anthony J. Griswold, Badri Narayan Vardarajan, Eden R. Martin et al. · 2023 · Alzheimer s & Dementia
49. Apolipoprotein E deficiency potentiates macrophage against Staphylococcus aureus in mice with osteomyelitis via regulating cholesterol metabolism
    Mincheng Lu, Ruiyi He, Chao Li, Zixian Liu, Yuhui Chen, Bingsheng Yang, Xianrong Zhang, Bin Yu · 2023 · Frontiers in Cellular and Infection Microbiology
50. Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan
    Simon T. Dillon, Hasan H. Otu, Long H. Ngo, Tamara G. Fong, Sarinnapha M. Vasunilashorn, Zhongcong Xie, Lisa J. Kunze, Kamen V. Vlassakov, Ayesha R. Abdeen, Jeffrey K. Lange et al. · 2022 · Anesthesia & Analgesia
51. Analysis of early effects of human APOE isoforms on Alzheimer’s disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE
    Yesiltepe, Metin, Yin, Tao, Tambini, Marc, Bao, Hanmei, Pan, Meixia, d’Abramo, Cristina, Giliberto, Luca, Han, Xianlin, D’Adamio, Luciano · 2024 · Cell Communication and Signaling
52. Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele
    Xiaoyu Ji, Xinyuan Peng, Hailiang Tang, Hui Pan, W.D. Wang, Jie Wu, Jian Chen, Naili Wei · 2023 · Brain Pathology
53. ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice
    Weifen Li, Tahir Ali, Kaiwu He, Chengyou Zheng, Ningning Li, Zhijian Yu, Shupeng Li · 2024 · Journal of Cellular and Molecular Medicine
54. Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human APOE4
    Sarah B. Scheinman, Steve Zaldua, Adedoyin Dada, Kateryna Krochmaliuk, Katherine Dye, Felecia M. Marottoli, Gregory R. J. Thatcher, Leon M. Tai · 2021 · Frontiers in Neuroscience
55. The Role of APOE and NF-κB in Alzheimer’s Disease
    Don A. Davies · 2021 · Immuno
56. High-density lipoprotein: a biomarker and therapeutic target in sepsis
    Mohan Li, Marina Barros-Pinkelnig, M. Sesmu Arbous, Christina Christoffersen, Patrick C.N. Rensen, Sander Kooijman · 2025 · Critical Care
57. Modeling sporadic Alzheimer’s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors
    Kiruthika Ganesan, Peggy Rentsch, Alexander Langdon, Luke T. Milham, Bryce Vissel · 2024 · Frontiers in Aging Neuroscience
58. APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice
    Ye Zhou, Wenjuan Zhao, Nour Al‐Muhtasib, George William Rebeck · 2015 · Journal of Alzheimer s Disease
59. Effects of obesogenic diet and 17β-estradiol in female mice with APOE 3/3, 3/4, and 4/4 genotypes
    Amy Christensen, Cassandra Joan McGill, Wenjie Qian, Christian J. Pike · 2024 · Frontiers in Aging Neuroscience
60. Chemotherapy promotes astrocytic response to Aβ deposition, but not Aβ levels, in a mouse model of amyloid and APOE
    Christi Anne S. Ng, Lucas P. Biran, Elena Galvano, Jeanne S. Mandelblatt, Stefano Vicini, George William Rebeck · 2022 · Neurobiology of Disease
61. Correlation between genetic polymorphisms in apolipoprotein E and atrial fibrillation
    Yilian Wang, Huankun Lou, Minglang Wang, Jiahui Mei, Tuanjie Xing, Feixiang Wang, Zheng Dong, Luoqing Wang, Rongyuan Cao, Li Yao et al. · 2022 · Revista Portuguesa de Cardiologia
62. Potential mechanisms underlying lithium treatment for Alzheimer’s disease and COVID-19
    H.-F. Wei, S. Anchipolovsky, R. Vera, G. Liang, D. Chuang · 2022 · European Review for Medical and Pharmacological Sciences
63. ApoE4 Exacerbates Hippocampal Pathology Following Acute Brain Penetration Injury in Female Mice
    Hila Ben‐Moshe, Ishai Luz, Ori Liraz, Anat Boehm‐Cagan, Shiran Salomon‐Zimri, Daniel M. Michaelson · 2019 · Journal of Molecular Neuroscience
64. Temporal Characterization of the Amyloidogenic APPswe/PS1dE9;hAPOE4 Mouse Model of Alzheimer’s Disease
    Martine B. Grenon, Maria-Tzousi Papavergi, Praveen Bathini, Martin J. Sadowski, Cynthia Ann Lemere · 2024 · International Journal of Molecular Sciences
65. New APOE-related therapeutic options for Alzheimer’s disease
    Ziying Li · 2019 · AIP conference proceedings
66. Relation between Apolipoprotein E in Alzheimer’s Disease and SARS-CoV-2 and their Treatment Strategy: A Review
    Anu Kunnath Ramachandran, Subham Das, Gurupur Gautham Shenoy, Jayesh Mudgal, Alex Joseph · 2022 · CNS & Neurological Disorders - Drug Targets
67. Apolipoprotein E loss of function: Influence on murine brain markers of physiology and pathology
    Heather M. Buchanan, Claire E. Hull, Maria Cacho Barraza, Mirela Delibegović, Bettina Platt · 2022 · Aging Brain
68. Curcumin inhibits APOE4-induced injury by activating peroxisome proliferator-activated receptor-γ (PPARγ) in SH-SY5Y cells.
    Minghui Wang, Jie‐Jian Kou, Chunli Wang, Xiuying Yu, Xinmei Xie, Xiaobin Pang · 2020 · Europe PMC (PubMed Central)
69. APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes
    Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
70. Adverse Outcome Pathways Applied to Space Radiation Research
    Vinita Chauhan, Veronica S. Grybas, Devyn Hoopfer, Casey Higginson, Elizabeth A. Ainsbury, Omid Azimzadeh, Afshin Beheshti, Steve R. Blattnig, Marjan Boerma, Sylvain V. Costes et al. · 2025 · Environmental and Molecular Mutagenesis
71. Thrombomodulin Improves Cognitive Deficits in Heat-Stressed Mice
    Cheng‐Hsien Lin, Ling‐Yu Tang, Lin‐Yu Wang, Ching‐Ping Chang · 2024 · The International Journal of Neuropsychopharmacology
72. APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease
    Marta Moreno‐Rodríguez, Sylvia E. Perez, Michael H. Malek‐Ahmadi, Elliott Jay Mufson · 2025 · Journal of Neuroinflammation
73. Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer’s Disease
    Takahisa Kanekiyo, Guojun Bu · 2016 · Elsevier eBooks
74. A diet rich in docosahexaenoic acid enhances reactive astrogliosis and ramified microglia morphology in apolipoprotein E epsilon 4-targeted replacement mice
    Hillary Chappus-McCendie, Marc-Antoine Poulin, Raphaël Chouinard‐Watkins, Milène Vandal, Frédéric Calon, Marc-Antoine Lauzon, Mélanie Plourde · 2022 · Aging Brain
75. The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice
    Anneloes Martinsen, Rasha N.M. Saleh, Raphaël Chouinard‐Watkins, Richard Paul Bazinet, Glenn Harden, James Dick, Noemı́ Tejera, Matthew G. Pontifex, David Vauzour, Anne Marie Minihane · 2023 · Nutrients
76. Global research trends of Apolipoprotein E in central nervous system: A scientometric analysis
    Kai Gong, Yuhua Chen, Wei Liu, Zhanxiang Wang · 2021 · International Immunopharmacology
77. Lipids and Lipoproteins in Alzheimer’s Disease
    Sophie K. Stukas, Iva Kulić, Shahab Zareyan, Cheryl Lea Wellington · 2015 · InTech eBooks
78. The Alzheimer’s disease risk factor APOE4 drives pro-inflammation in human astrocytes via HDAC-dependent repression of TAGLN3
    Laurie Arnaud, Philippe D. Benech, Louise Greetham, Delphine Stephan, Angélique Jimenez, Nicolas D. Jullien, Laura García‐González, Philipp O. Tsvetkov, François Devred, Ignacio Sancho-Martinez et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
79. Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life
    Lindsey Isla Sinclair, Seth Love · 2017 · Journal of Alzheimer s Disease
80. The Impact of Apolipoprotein E Allelic Variants on Alzheimer’s Disease
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81. Genetic insights into drug targets for alzheimer’s disease: integrative multi-omics analysis
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82. Viral modulation of synaptic pruning: implications for neuropathology and brain function
    Shayan Aliakbari, Sareh Asadi, Mohammad Sayyah, Nima Naderi, Shakiba Salarvandian, Fariba Khodagholi, Hamid Gholami Pourbadie · 2026 · Journal of Virology
83. Apolipoprotein E genotype affects innate susceptibility to Listeria monocytogenes infection in aged male mice
    Jooyoung Cho, Katie L. Alexander, Jessica L. Ferrell, Lance A. Johnson, Steven Estus, Sarah E. F. D’Orazio · 2023 · Infection and Immunity
84. Associations of ApoE Polymorphisms with Postoperative Atrial Fibrillation and Cardiac Injury in Patients with Coronary Artery Bypass Graft Surgery
    Hui Xue, Lixin Fan, Chen Liu · 2023 · International Heart Journal
85. Apolipoprotein E and Mimetics as Targets and Therapeutics for Alzheimer’s Disease
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86. Melatoninergic Pathways in Alzheimer's Disease
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87. The roles of apolipoprotein E ε4 on neuropathology and neuroinflammation in patients with Alzheimer's disease
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88. Sensitivity analysis of a mathematical model of Alzheimer's disease progression unveils important causal pathways
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89. A Double-Edged Sword: Ethical and Psychological Implications of APOE Genotype Disclosure Across the Lifespan
    Diego Iacono · 2025 · Neuroethics
90. APOE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes
    Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac et al. · 2026 · Journal of Neuroinflammation
91. Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits
    Nardos G. Tassew, Steven T. Laing, Whitney Shatz-Binder, Susan Ritger Crowell, Kelly M. Loyet, Chris Schuetz, Craig Blanchette · 2020 · Toxicologic Pathology
92. Effects of sex and genotype in human APOE‐targeted replacement mice on alcohol self‐administration measured with the automated IntelliCage system before and after repeated mild traumatic brain injury
    Kathryn E. Simmons, Kati L. Healey, Qiang Li, Scott D. Moore, Rebecca C. Klein · 2021 · Alcoholism Clinical and Experimental Research
93. Region-Specific Differences in the Apoe4-dependent Response to Focal Brain Injury
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94. Advances in hiPSC ‐Derived Brain Organoids as a Model to Study Neuroinflammation in Alzheimer's Disease
    Esther M. A. Maciel, Nathalia Costa Silva, Luiz Gustavo Pontes Santos, Fabiola Mara Ribeiro · 2026 · Journal of Neurochemistry
95. Apolipoprotein E ε4-Specific Relationship Between Serum Olfactomedin 4 and Alzheimer’s Disease
    Chunxiao Wei, Guimei Zhang, Xiaoshu Fu, Meng Liang Zhao, Weijie Zhai, Yanxin Shen, Li Sun · 2025 · Molecular Neurobiology
96. ApoE, Human Fertility, and Reproduction
    Bani Medegan Fagla, Leon M. Tai, Irina Alexandra Buhimschi · 2025 · Springer eBooks
97. WITHDRAWN: Apolipoprotein E4 expressed by microglia impairs microglial functions and enhances neurotoxicity
    Na Wang, Min Wei, Xinxiu Li, Lin Jia, Jianguo Li, Huaxi Xu, Yun‐wu Zhang, Honghua Zheng · 2020 · Research Square
98. The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease
    Kitty B. Murphy, Di Hu, Leen Wolfs, Renzo Mancuso, Bart De Strooper, Sarah J. Marzi · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
99. APOE4 alters the lipid droplet proteome and modulates droplet dynamics
    Cassi M. Friday, Isaiah O. Stephens, Cathryn T Smith, Sangderk Lee, Diksha Satish, Nicholas A. Devanney, Sarah Cohen, Josh M. Morganti, Scott M. Gordon, Lance A. Johnson · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
100. Síntese de um potencial inibidor da B-secretase e sua interação com o enzima
     Rita Alexandra Gonçalves Pereira · 2012 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)