Effects of Microglia on Neurogenesis
Open accessAbstract
This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis. GLIA 2015;63:1394–1405
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Microglia constitute a prominent cell population within the hippocampal neurogenic niche.
“Microglia constitute a prominent cell population within the hippocampal neurogenic niche (8).”
From IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis (2021) · cites this paper as [8]
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References 160 · Cited by 187
Research works printed but not linked: 1
- Garcia‐Verdugo JM, Doetsch F, Wichterle H, Lim DA, Alvarez‐Buylla A. 1998 Architecture and cell types of the adult subventricular zone: In search of the stem cells. J Neurobiol 36: 234– 248. 9712307
- Authors
- Sato, K.
- Affiliations
- National Institute of Health Sciences (JP)
- Corresponding author
- Sato, Kaoru
- ORCID
- Sato, Kaoru
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2015-05-24
- Volume
- 63
- Issue
- 8
- Pages
- 1394-1405
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- PMC
- PMC5032973
- OpenAlex
- W1955481428
- Cited by
- 187
- References
- 160
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 9 · 2023: 16 · 2022: 19 · 2021: 23 · 2020: 19 · 2019: 23 · 2018: 18 · 2017: 15 · 2016: 16 · 2015: 4
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Glia (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- AMED, Japan (the Research Grants on Regulatory Science of Pharmaceuticals and Medical Devices)
- MHLW, Japan (a Grant for Research on Risks of Chemicals, a Research Grant for Research on New Drug Development, the Research Grants on Regulatory Science of Pharmaceuticals and Medical Devices)
- NIBIO, Japan (the Program for Promotion of Fundamental Studies in Health Sciences)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- microglia, neurogenesis, subgranular zone, hippocampus, subventricular zone, lateral ventricle, adult neurogenesis
- MeSH terms
- Animals, Brain, Humans, Microglia, Stem Cell Niche, Neurogenesis, Neural Stem Cells
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