Cuprizone-induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage-inducible transcript 3

Fischbach, Felix; Nedelcu, Julia; Leopold, Patrizia; Zhan, Jiangshan; Clarner, Tim; Nellessen, Lara; Beißel, Christian; van Heuvel, Yasemin; Goswami, Anand; Weis, Joachim; Denecke, Bernd; Schmitz, Christoph; Hochstrasser, Tanja; Nyamoya, Stella; Victor, Marion; Beyer, Cordian; Kipp, Markus

doi:10.1002/glia.23538

Cuprizone-induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage-inducible transcript 3

Oligodendrocytes are integral to efficient neuronal signaling. Loss of myelinating oligodendrocytes is a central feature of many neurological diseases, including multiple sclerosis (MS). The results of neuropathological studies suggest that oligodendrocytes react with differing sensitivity to tox…