Priming of microglia with IFN ‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects

Zhang, Jinqiang; He, Hui; Qiao, Yan; Zhou, Tao; He, Haili; Yi, Saini; Zhang, Lijuan; Mo, Li; Li, Yahui; Jiang, Weike; You, Zili

doi:10.1002/glia.23878

Priming of microglia with IFN ‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects

Neuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on hippocampal neurogenesis and behavior are unclear. In the present study, IFN‐γ was administered to mice via intracerebrovent…