Regional cerebral blood flow in children with attention deficit hyperactivity disorder: Comparison before and after methylphenidate treatment
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Differences in brain activity of children with attention deficit hyperactivity disorder (ADHD) have been compared to normal healthy controls, suggesting neural correlates of cognitive/behavioral symptoms. Symptoms are improved with methylphenidate treatment but limited sources can be cited to show how brain activity in ADHD is altered after pharmacologic treatment. We investigated how long‐term oral medication of methylphenidate affects the resting regional cerebral blood flow (rCBF) in ADHD children, using single photon emission computerized tomography (SPECT). rCBF was decreased in the orbitofrontal cortex and middle temporal gyrus in the right hemisphere whereas it was increased in the dorsomedial prefrontal and somatosensory area bilaterally in drug‐naïve ADHD children compared to control child subjects. After treatment with methylphenidate, the extent of hyperperfusion in the somatosensory area was reduced and significant reduction of rCBF was found in the right striatum for the first time. Methylphenidate treatment also resulted in rCBF increase in superior prefrontal and reduction in ventral higher visual areas bilaterally. The results indicated that improving ADHD symptom after methylphenidate is associated with normalization of abnormally reduced orbitofrontal activity and abnormally increased somatosensory cortical activity. These changes were accompanied with reduced striatum activity lower than that of normal controls. These changes might be associated with improving ADHD to control attention and motor response to irrelevant environmental stimuli after methylphenidate treatment. Hum. Brain Mapp 24:157–164, 2005. © 2004 Wiley‐Liss, Inc.
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Treatment with methylphenidate normalizes the hypoperfusion of prefrontal areas and is associated with corresponding improvement in ADHD symptoms.
“treatment with methylphenidate normalizes the hypoperfusion of prefrontal areas and is associated with corresponding improvement in ADHD symptoms [60][61][62][63][64][65].”
From Adult ADHD and comorbid disorders: clinical implications of a dimensional approach (2017) · cites this paper as [61]
The Results report that prefrontal and orbitofrontal hypoperfusion recovered to normal levels after methylphenidate treatment, and that ADHD symptoms improved. The Discussion says the normalization *may* be associated with symptom improvement; the claim presents that association as established. (LLM, conf=0.84)
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References 28 · Cited by 134
Research works printed but not linked: 1
- Chang LT (1978): A method of attenuation correction in radio- nuclide computed tomography. IEEE Trans Nucl Sci 25:638 - 643.
- Authors
- Lee, J. S., Kim, B. N., Kang, E., Lee, D. S., Kim, Y. K., Chung, J., Lee, M. C., & Cho, S. C.
- Affiliations
- Seoul National University (KR)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2004-10-18
- Volume
- 24
- Issue
- 3
- Pages
- 157-164
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6871721
- OpenAlex
- W2044798205
- Cited by
- 134
- References
- 28
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 8 · 2013: 12 · 2012: 6
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, methylphenidate, regional cerebral blood flow, resting-state brain activity, orbitofrontal cortex, somatosensory cortex, striatum, prefrontal cortex, middle temporal gyrus, SPECT, children
- MeSH terms
- Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Cerebrovascular Circulation, Child, Female, Humans, Image Processing, Computer-Assisted, Male, Methylphenidate, Regional Blood Flow, Tomography, Emission-Computed, Single-Photon
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