Mesolimbic recruitment by nondrug rewards in detoxified alcoholics: effort anticipation, reward anticipation, and reward delivery

Abstract

Aberrant sensitivity of incentive neurocircuitry to nondrug rewards has been suggested as either a risk factor for or consequence of drug addiction. Using functional magnetic resonance imaging, we tested whether alcohol‐dependent patients (ADP: n = 29) showed altered recruitment of ventral striatal (VS) incentive neurocircuitry compared to controls (n = 23) by: (1) cues to respond for monetary rewards, (2) post‐response anticipation of rewards, or (3) delivery of rewards. Using an instrumental task with two‐stage presentation of reward‐predictive information, subjects saw cues signaling opportunities to win $0, $1, or $10 for responding to a target. Following this response, subjects were notified whether their success would be indicated by a lexical notification (“Hit?”) or by delivery of a monetary reward (“Win?”). After a variable interval, subjects then viewed the trial outcome. We found no significant group differences in voxelwise activation by task contrasts, or in signal change extracted from VS. Both ADP and controls showed significant VS and other limbic recruitment by pre‐response reward anticipation. In addition, controls also showed VS recruitment by post‐response reward‐anticipation, and ADP had appreciable subthreshold VS activation. Both groups also showed similar mesolimbic responses to reward deliveries. Across all subjects, a questionnaire measure of “hot” impulsivity correlated with VS recruitment by post‐response anticipation of low rewards and with VS recruitment by delivery of low rewards. These findings indicate that incentive‐motivational processing of nondrug rewards is substantially maintained in recovering alcoholics, and that reward‐elicited VS recruitment correlates more with individual differences in trait impulsivity irrespective of addiction. Hum Brain Mapp 33:2174–2188, 2012. Published 2011 Wiley Periodicals, Inc.